Between August 30, 1971 and July 21, 2017, Nolan Ryan struck out the most hitters, with 5,241 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,241 | 708 | 296 | 257 | .535 | 704 | 3.17 | 209 | 59 | 1 | 4894.1 | 3,574 | 1,725 | 1,967 | 287 | 2,472 | 138 | 3 | 65 | 20,449 | 255 | 9.64 | 4.55 | 2.12 | 0.53 | 25.6 | 12.1 | 1.24 | .267 | 3.62 | 6.57 |
| 2 |  | R. Johnson | 4,875 | 618 | 303 | 166 | .646 | 603 | 3.29 | 100 | 37 | 2 | 4135.1 | 3,346 | 1,513 | 1,703 | 411 | 1,497 | 190 | 7 | 37 | 17,067 | 109 | 10.61 | 3.26 | 3.26 | 0.89 | 28.6 | 8.8 | 1.17 | .291 | 3.71 | 7.28 |
| 3 |  | R. Clemens | 4,672 | 709 | 354 | 184 | .658 | 707 | 3.12 | 118 | 46 | 0 | 4916.2 | 4,185 | 1,707 | 1,885 | 363 | 1,580 | 159 | 0 | 63 | 20,240 | 143 | 8.55 | 2.89 | 2.96 | 0.66 | 23.1 | 7.8 | 1.17 | .284 | 3.45 | 7.66 |
| 4 |  | B. Blyleven | 3,388 | 634 | 266 | 226 | .541 | 629 | 3.32 | 225 | 56 | 0 | 4588.0 | 4,277 | 1,694 | 1,879 | 394 | 1,228 | 148 | 2 | 64 | 18,931 | 108 | 6.65 | 2.41 | 2.76 | 0.77 | 17.9 | 6.5 | 1.20 | .282 | 3.69 | 8.39 |
| 5 |  | G. Maddux | 3,371 | 744 | 355 | 227 | .610 | 740 | 3.16 | 109 | 35 | 0 | 5008.1 | 4,726 | 1,756 | 1,981 | 353 | 999 | 137 | 3 | 177 | 20,421 | 70 | 6.06 | 1.80 | 3.37 | 0.63 | 16.5 | 4.9 | 1.14 | .281 | 3.56 | 8.49 |
| 6 |  | S. Carlton | 3,207 | 558 | 255 | 184 | .581 | 544 | 3.26 | 191 | 40 | 1 | 4002.0 | 3,556 | 1,451 | 1,659 | 331 | 1,401 | 37 | 6 | 111 | 16,590 | 133 | 7.21 | 3.15 | 2.29 | 0.74 | 19.3 | 8.4 | 1.24 | .278 | 3.73 | 8.00 |
| 7 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 8 | | C. Schilling | 3,116 | 569 | 216 | 146 | .597 | 436 | 3.46 | 83 | 20 | 22 | 3261.0 | 2,998 | 1,253 | 1,318 | 347 | 711 | 52 | 81 | 43 | 13,284 | 72 | 8.60 | 1.96 | 4.38 | 0.96 | 23.5 | 5.4 | 1.14 | .293 | 3.64 | 8.27 |
| 9 |  | J. Smoltz | 3,084 | 723 | 213 | 155 | .579 | 481 | 3.33 | 53 | 16 | 154 | 3473.0 | 3,074 | 1,284 | 1,391 | 288 | 1,010 | 57 | 204 | 84 | 14,271 | 145 | 7.99 | 2.62 | 3.05 | 0.75 | 21.6 | 7.1 | 1.18 | .283 | 3.60 | 7.97 |
| 10 | | M. Mussina | 2,813 | 537 | 270 | 153 | .638 | 536 | 3.68 | 57 | 23 | 0 | 3562.2 | 3,460 | 1,458 | 1,559 | 376 | 785 | 60 | 0 | 29 | 14,593 | 71 | 7.11 | 1.98 | 3.58 | 0.95 | 19.3 | 5.4 | 1.19 | .292 | 3.94 | 8.74 |
| 11 |  | CC Sabathia | 2,797 | 498 | 232 | 144 | .617 | 498 | 3.69 | 38 | 12 | 0 | 3257.1 | 3,082 | 1,337 | 1,460 | 324 | 994 | 108 | 0 | 43 | 13,609 | 70 | 7.73 | 2.75 | 2.81 | 0.90 | 20.6 | 7.3 | 1.25 | .294 | 4.03 | 8.52 |
| 12 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 13 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 14 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 15 | | T. Glavine | 2,607 | 682 | 305 | 203 | .600 | 682 | 3.54 | 56 | 25 | 0 | 4413.1 | 4,298 | 1,734 | 1,900 | 356 | 1,500 | 66 | 0 | 145 | 18,604 | 65 | 5.32 | 3.06 | 1.74 | 0.73 | 14.0 | 8.1 | 1.31 | .280 | 3.87 | 8.76 |
| 16 |  | T. Seaver | 2,548 | 483 | 221 | 153 | .591 | 479 | 3.04 | 147 | 44 | 0 | 3464.2 | 2,911 | 1,169 | 1,286 | 285 | 1,051 | 49 | 1 | 87 | 14,106 | 94 | 6.62 | 2.73 | 2.42 | 0.74 | 18.1 | 7.5 | 1.14 | .258 | 3.34 | 7.56 |
| 17 | | J. Vazquez | 2,536 | 450 | 165 | 160 | .508 | 443 | 4.22 | 28 | 8 | 0 | 2840.0 | 2,784 | 1,331 | 1,431 | 373 | 763 | 88 | 5 | 58 | 11,935 | 76 | 8.04 | 2.42 | 3.32 | 1.18 | 21.2 | 6.4 | 1.25 | .295 | 4.53 | 8.82 |
| 18 | | A.J. Burnett | 2,513 | 435 | 164 | 157 | .511 | 430 | 3.99 | 24 | 10 | 0 | 2731.1 | 2,519 | 1,210 | 1,328 | 263 | 1,100 | 143 | 1 | 35 | 11,665 | 161 | 8.28 | 3.62 | 2.28 | 0.87 | 21.5 | 9.4 | 1.32 | .295 | 4.38 | 8.30 |
| 19 | | P. Niekro | 2,488 | 593 | 239 | 205 | .538 | 564 | 3.49 | 174 | 29 | 8 | 4061.2 | 3,840 | 1,574 | 1,803 | 362 | 1,466 | 91 | 19 | 58 | 17,161 | 149 | 5.51 | 3.25 | 1.70 | 0.80 | 14.5 | 8.5 | 1.31 | .273 | 4.00 | 8.51 |
| 20 | | D. Sutton | 2,479 | 555 | 246 | 172 | .589 | 551 | 3.23 | 125 | 40 | 2 | 3854.1 | 3,395 | 1,382 | 1,530 | 358 | 958 | 54 | 3 | 55 | 15,740 | 79 | 5.79 | 2.24 | 2.59 | 0.84 | 15.7 | 6.1 | 1.13 | .255 | 3.57 | 7.93 |
| 21 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 22 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 23 | | A. Pettitte | 2,448 | 531 | 256 | 153 | .626 | 521 | 3.85 | 26 | 4 | 0 | 3316.0 | 3,448 | 1,418 | 1,572 | 288 | 1,031 | 55 | 3 | 42 | 14,074 | 69 | 6.64 | 2.80 | 2.37 | 0.78 | 17.4 | 7.3 | 1.35 | .308 | 4.27 | 9.36 |
| 24 | | J. Moyer | 2,441 | 696 | 269 | 209 | .563 | 638 | 4.25 | 33 | 10 | 0 | 4074.0 | 4,231 | 1,926 | 2,076 | 522 | 1,155 | 146 | 15 | 69 | 17,356 | 57 | 5.39 | 2.55 | 2.11 | 1.15 | 14.1 | 6.7 | 1.32 | .283 | 4.59 | 9.35 |
| 25 |  | B. Colon | 2,410 | 523 | 235 | 171 | .579 | 514 | 4.02 | 36 | 13 | 0 | 3239.1 | 3,329 | 1,448 | 1,580 | 390 | 908 | 61 | 1 | 46 | 13,698 | 43 | 6.70 | 2.52 | 2.65 | 1.08 | 17.6 | 6.6 | 1.31 | .296 | 4.39 | 9.25 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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89 | 63 | .586 | ||
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