Between January 1, 1978 and August 28, 2000, Roger Clemens struck out the most batters, with 3,466 strikeouts.
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Clemens | 3,466 | 506 | 258 | 140 | .648 | 505 | 3.06 | 116 | 45 | 0 | 3627.2 | 3,067 | 1,235 | 1,368 | 254 | 1,174 | 122 | 0 | 44 | 14,929 | 92 | 8.60 | 2.91 | 2.95 | 0.63 | 23.2 | 7.9 | 1.17 | .284 | 3.39 | 7.61 |
| 2 |  | N. Ryan | 3,288 | 476 | 183 | 160 | .534 | 476 | 3.29 | 84 | 27 | 0 | 3152.0 | 2,386 | 1,151 | 1,311 | 199 | 1,411 | 87 | 0 | 46 | 13,116 | 174 | 9.39 | 4.03 | 2.33 | 0.57 | 25.1 | 10.8 | 1.20 | .269 | 3.74 | 6.81 |
| 3 |  | R. Johnson | 2,971 | 359 | 176 | 93 | .654 | 350 | 3.19 | 75 | 27 | 2 | 2451.2 | 1,886 | 868 | 980 | 216 | 1,073 | 106 | 4 | 16 | 10,183 | 79 | 10.91 | 3.94 | 2.77 | 0.79 | 29.2 | 10.5 | 1.21 | .287 | 3.60 | 6.92 |
| 4 |  | D. Cone | 2,522 | 414 | 183 | 113 | .618 | 385 | 3.35 | 56 | 22 | 1 | 2722.0 | 2,302 | 1,013 | 1,110 | 235 | 1,048 | 93 | 9 | 36 | 11,362 | 138 | 8.34 | 3.47 | 2.41 | 0.78 | 22.2 | 9.2 | 1.23 | .277 | 3.67 | 7.61 |
| 5 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 6 |  | J. Morris | 2,450 | 542 | 253 | 185 | .578 | 521 | 3.90 | 174 | 28 | 0 | 3778.1 | 3,529 | 1,638 | 1,795 | 385 | 1,367 | 58 | 10 | 99 | 15,931 | 203 | 5.84 | 3.26 | 1.79 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.28 | 8.41 |
| 7 |  | G. Maddux | 2,310 | 465 | 235 | 134 | .637 | 461 | 2.84 | 97 | 29 | 0 | 3273.2 | 2,957 | 1,032 | 1,185 | 175 | 729 | 87 | 3 | 129 | 13,300 | 47 | 6.35 | 2.00 | 3.17 | 0.48 | 17.4 | 5.5 | 1.13 | .278 | 3.26 | 8.13 |
| 8 | | C. Finley | 2,307 | 463 | 175 | 150 | .538 | 406 | 3.76 | 60 | 14 | 0 | 2847.2 | 2,714 | 1,191 | 1,325 | 272 | 1,205 | 72 | 24 | 30 | 12,149 | 125 | 7.29 | 3.81 | 1.91 | 0.86 | 19.0 | 9.9 | 1.38 | .294 | 4.19 | 8.58 |
| 9 | | D. Gooden | 2,279 | 423 | 193 | 111 | .635 | 409 | 3.50 | 68 | 24 | 2 | 2779.0 | 2,536 | 1,080 | 1,184 | 206 | 945 | 78 | 2 | 41 | 11,603 | 75 | 7.38 | 3.06 | 2.41 | 0.67 | 19.6 | 8.1 | 1.25 | .288 | 3.83 | 8.21 |
| 10 |  | J. Smoltz | 2,098 | 356 | 157 | 113 | .581 | 356 | 3.35 | 47 | 14 | 0 | 2414.1 | 2,092 | 898 | 986 | 195 | 774 | 38 | 0 | 55 | 9,947 | 119 | 7.82 | 2.89 | 2.71 | 0.73 | 21.1 | 7.8 | 1.19 | .277 | 3.68 | 7.80 |
| 11 | | F. Valenzuela | 2,074 | 453 | 173 | 153 | .531 | 424 | 3.54 | 113 | 31 | 2 | 2930.0 | 2,718 | 1,154 | 1,303 | 226 | 1,151 | 25 | 10 | 65 | 12,398 | 119 | 6.37 | 3.54 | 1.80 | 0.69 | 16.7 | 9.3 | 1.32 | .279 | 4.00 | 8.35 |
| 12 | | D. Martinez | 2,024 | 646 | 230 | 184 | .556 | 547 | 3.69 | 116 | 30 | 4 | 3805.1 | 3,717 | 1,559 | 1,741 | 361 | 1,093 | 114 | 31 | 65 | 15,939 | 78 | 4.79 | 2.59 | 1.85 | 0.85 | 12.7 | 6.9 | 1.26 | .272 | 4.12 | 8.79 |
| 13 | | O. Hershiser | 2,014 | 510 | 204 | 150 | .576 | 466 | 3.48 | 68 | 25 | 5 | 3130.1 | 2,939 | 1,211 | 1,367 | 235 | 1,007 | 117 | 19 | 108 | 13,150 | 121 | 5.79 | 2.90 | 2.00 | 0.68 | 15.3 | 7.7 | 1.26 | .277 | 3.93 | 8.45 |
| 14 | | C. Hough | 1,993 | 573 | 182 | 183 | .499 | 439 | 3.86 | 107 | 13 | 9 | 3278.2 | 2,900 | 1,405 | 1,602 | 341 | 1,383 | 140 | 64 | 31 | 13,944 | 152 | 5.47 | 3.80 | 1.44 | 0.94 | 14.3 | 9.9 | 1.31 | .254 | 4.40 | 7.96 |
| 15 | | B. Blyleven | 1,973 | 410 | 165 | 137 | .546 | 406 | 3.71 | 112 | 25 | 0 | 2826.1 | 2,752 | 1,166 | 1,276 | 282 | 769 | 97 | 1 | 41 | 11,798 | 68 | 6.28 | 2.45 | 2.57 | 0.90 | 16.7 | 6.5 | 1.25 | .285 | 4.06 | 8.76 |
| 16 | | B. Welch | 1,969 | 506 | 211 | 146 | .591 | 462 | 3.47 | 61 | 28 | 8 | 3092.0 | 2,894 | 1,191 | 1,310 | 267 | 1,034 | 79 | 20 | 60 | 12,956 | 55 | 5.73 | 3.01 | 1.90 | 0.78 | 15.2 | 8.0 | 1.27 | .273 | 3.81 | 8.42 |
| 17 | | D. Darwin | 1,942 | 716 | 171 | 182 | .484 | 371 | 3.84 | 53 | 9 | 32 | 3016.2 | 2,951 | 1,286 | 1,432 | 321 | 874 | 81 | 171 | 101 | 12,716 | 52 | 5.79 | 2.61 | 2.22 | 0.96 | 15.3 | 6.9 | 1.27 | .277 | 4.27 | 8.80 |
| 18 | | B. Witt | 1,924 | 416 | 138 | 156 | .469 | 390 | 4.84 | 47 | 11 | 0 | 2421.2 | 2,457 | 1,301 | 1,426 | 246 | 1,350 | 36 | 13 | 36 | 10,810 | 126 | 7.15 | 5.02 | 1.43 | 0.91 | 17.8 | 12.5 | 1.57 | .305 | 5.30 | 9.13 |
| 19 | | K. Brown | 1,873 | 376 | 169 | 113 | .599 | 374 | 3.23 | 70 | 17 | 0 | 2619.2 | 2,461 | 939 | 1,081 | 158 | 724 | 114 | 1 | 36 | 10,883 | 84 | 6.43 | 2.49 | 2.59 | 0.54 | 17.2 | 6.7 | 1.22 | .287 | 3.71 | 8.45 |
| 20 | | D. Eckersley | 1,858 | 968 | 157 | 139 | .530 | 274 | 3.57 | 73 | 12 | 387 | 2652.1 | 2,560 | 1,052 | 1,139 | 287 | 516 | 56 | 569 | 69 | 10,913 | 15 | 6.30 | 1.75 | 3.60 | 0.97 | 17.0 | 4.7 | 1.16 | .277 | 3.86 | 8.69 |
| 21 | | A. Benes | 1,850 | 353 | 141 | 126 | .528 | 348 | 3.85 | 20 | 9 | 1 | 2283.1 | 2,156 | 978 | 1,064 | 247 | 791 | 43 | 2 | 49 | 9,654 | 62 | 7.29 | 3.12 | 2.34 | 0.97 | 19.2 | 8.2 | 1.29 | .284 | 4.19 | 8.50 |
| 22 | | F. Viola | 1,844 | 421 | 176 | 150 | .540 | 420 | 3.73 | 74 | 16 | 0 | 2836.1 | 2,827 | 1,175 | 1,303 | 294 | 864 | 48 | 0 | 39 | 11,933 | 86 | 5.85 | 2.74 | 2.13 | 0.93 | 15.5 | 7.2 | 1.30 | .285 | 4.13 | 8.97 |
| 23 | | F. Tanana | 1,836 | 496 | 174 | 187 | .482 | 479 | 4.00 | 70 | 15 | 1 | 3106.1 | 3,157 | 1,379 | 1,555 | 355 | 963 | 93 | 7 | 99 | 13,262 | 92 | 5.32 | 2.79 | 1.91 | 1.03 | 13.8 | 7.3 | 1.33 | .280 | 4.51 | 9.15 |
| 24 |  | S. Carlton | 1,827 | 323 | 138 | 108 | .561 | 309 | 3.43 | 79 | 20 | 1 | 2230.2 | 2,034 | 849 | 977 | 190 | 783 | 20 | 6 | 68 | 9,306 | 89 | 7.37 | 3.16 | 2.33 | 0.77 | 19.6 | 8.4 | 1.26 | .284 | 3.94 | 8.21 |
| 25 | | T. Glavine | 1,779 | 427 | 204 | 122 | .626 | 427 | 3.41 | 47 | 19 | 0 | 2850.2 | 2,712 | 1,080 | 1,198 | 196 | 957 | 38 | 0 | 92 | 11,972 | 55 | 5.62 | 3.02 | 1.86 | 0.62 | 14.9 | 8.0 | 1.29 | .279 | 3.78 | 8.56 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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| NL Central | W | L | PCT | GB |
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