Between May 13, 1966 and September 17, 2003, Nolan Ryan fanned the most batters, with 5,714 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,714 | 807 | 324 | 292 | .526 | 773 | 3.19 | 222 | 61 | 3 | 5386.0 | 3,923 | 1,911 | 2,178 | 321 | 2,795 | 158 | 13 | 78 | 22,575 | 277 | 9.55 | 4.67 | 2.04 | 0.54 | 25.3 | 12.4 | 1.25 | .265 | 3.64 | 6.56 |
| 2 |  | S. Carlton | 4,115 | 726 | 329 | 244 | .574 | 707 | 3.22 | 254 | 55 | 2 | 5192.2 | 4,645 | 1,857 | 2,123 | 411 | 1,825 | 52 | 8 | 149 | 21,578 | 178 | 7.13 | 3.16 | 2.25 | 0.71 | 19.1 | 8.5 | 1.25 | .279 | 3.68 | 8.05 |
| 3 |  | R. Clemens | 4,093 | 605 | 308 | 160 | .658 | 604 | 3.20 | 117 | 46 | 0 | 4265.2 | 3,670 | 1,515 | 1,670 | 321 | 1,375 | 140 | 0 | 52 | 17,603 | 125 | 8.64 | 2.90 | 2.98 | 0.68 | 23.3 | 7.8 | 1.18 | .287 | 3.52 | 7.74 |
| 4 |  | R. Johnson | 3,857 | 452 | 229 | 114 | .668 | 442 | 3.10 | 88 | 35 | 2 | 3110.1 | 2,418 | 1,073 | 1,211 | 281 | 1,256 | 145 | 5 | 22 | 12,846 | 92 | 11.16 | 3.63 | 3.07 | 0.81 | 30.0 | 9.8 | 1.18 | .292 | 3.50 | 7.00 |
| 5 |  | B. Blyleven | 3,701 | 692 | 287 | 250 | .534 | 685 | 3.31 | 242 | 60 | 0 | 4970.0 | 4,632 | 1,830 | 2,029 | 430 | 1,322 | 155 | 3 | 71 | 20,492 | 114 | 6.70 | 2.39 | 2.80 | 0.78 | 18.1 | 6.5 | 1.20 | .282 | 3.67 | 8.39 |
| 6 |  | T. Seaver | 3,640 | 656 | 311 | 205 | .603 | 647 | 2.86 | 231 | 61 | 1 | 4783.0 | 3,971 | 1,521 | 1,674 | 380 | 1,390 | 76 | 6 | 117 | 19,369 | 125 | 6.85 | 2.62 | 2.62 | 0.72 | 18.8 | 7.2 | 1.12 | .259 | 3.15 | 7.47 |
| 7 | | D. Sutton | 3,530 | 767 | 320 | 253 | .558 | 749 | 3.27 | 176 | 57 | 5 | 5228.1 | 4,646 | 1,900 | 2,089 | 468 | 1,335 | 81 | 12 | 102 | 21,416 | 111 | 6.08 | 2.30 | 2.64 | 0.81 | 16.5 | 6.2 | 1.14 | .261 | 3.60 | 8.00 |
| 8 | | P. Niekro | 3,278 | 801 | 314 | 268 | .540 | 715 | 3.35 | 245 | 45 | 23 | 5295.0 | 4,937 | 1,972 | 2,280 | 474 | 1,765 | 117 | 56 | 79 | 22,195 | 215 | 5.57 | 3.00 | 1.86 | 0.81 | 14.8 | 8.0 | 1.27 | .269 | 3.88 | 8.39 |
| 9 | | F. Jenkins | 3,161 | 650 | 281 | 225 | .555 | 594 | 3.35 | 267 | 49 | 5 | 4468.0 | 4,123 | 1,661 | 1,844 | 480 | 990 | 84 | 29 | 115 | 18,278 | 62 | 6.37 | 1.99 | 3.19 | 0.97 | 17.3 | 5.4 | 1.14 | .269 | 3.71 | 8.31 |
| 10 | | G. Perry | 3,102 | 636 | 285 | 235 | .548 | 629 | 3.05 | 288 | 50 | 3 | 4787.2 | 4,395 | 1,624 | 1,877 | 349 | 1,218 | 95 | 7 | 132 | 19,580 | 136 | 5.83 | 2.29 | 2.55 | 0.66 | 15.8 | 6.2 | 1.17 | .273 | 3.53 | 8.26 |
| 11 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 12 |  | G. Maddux | 2,763 | 573 | 287 | 163 | .638 | 569 | 2.89 | 103 | 34 | 0 | 3958.2 | 3,620 | 1,273 | 1,458 | 234 | 838 | 109 | 3 | 154 | 16,082 | 52 | 6.28 | 1.91 | 3.30 | 0.53 | 17.2 | 5.2 | 1.13 | .279 | 3.31 | 8.23 |
| 13 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 14 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 15 | | J. Koosman | 2,556 | 612 | 222 | 209 | .515 | 527 | 3.36 | 140 | 33 | 17 | 3839.1 | 3,635 | 1,433 | 1,608 | 290 | 1,198 | 71 | 43 | 121 | 15,996 | 89 | 5.99 | 2.81 | 2.13 | 0.68 | 16.0 | 7.5 | 1.26 | .282 | 3.77 | 8.52 |
| 16 | | C. Schilling | 2,540 | 449 | 163 | 116 | .584 | 337 | 3.32 | 79 | 19 | 13 | 2581.0 | 2,278 | 951 | 1,011 | 260 | 603 | 39 | 60 | 41 | 10,467 | 67 | 8.86 | 2.10 | 4.21 | 0.91 | 24.3 | 5.8 | 1.12 | .287 | 3.53 | 7.94 |
| 17 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 18 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 19 |  | P. Martinez | 2,413 | 353 | 165 | 67 | .711 | 286 | 2.60 | 41 | 15 | 3 | 2069.0 | 1,547 | 597 | 667 | 149 | 552 | 99 | 23 | 21 | 8,248 | 51 | 10.50 | 2.40 | 4.37 | 0.65 | 29.3 | 6.7 | 1.01 | .278 | 2.90 | 6.73 |
| 20 | | D. Eckersley | 2,401 | 1,071 | 197 | 171 | .535 | 361 | 3.50 | 100 | 20 | 390 | 3285.2 | 3,076 | 1,279 | 1,382 | 347 | 738 | 75 | 577 | 90 | 13,534 | 28 | 6.58 | 2.02 | 3.25 | 0.95 | 17.7 | 5.5 | 1.16 | .274 | 3.79 | 8.43 |
| 21 | | C. Hough | 2,362 | 858 | 216 | 216 | .500 | 440 | 3.75 | 107 | 13 | 61 | 3801.1 | 3,283 | 1,582 | 1,807 | 383 | 1,664 | 174 | 240 | 44 | 16,168 | 180 | 5.59 | 3.94 | 1.42 | 0.91 | 14.6 | 10.3 | 1.30 | .250 | 4.28 | 7.77 |
| 22 |  | J. Smoltz | 2,307 | 525 | 163 | 120 | .576 | 361 | 3.29 | 47 | 14 | 109 | 2614.2 | 2,249 | 955 | 1,047 | 208 | 816 | 40 | 141 | 59 | 10,730 | 122 | 7.94 | 2.81 | 2.83 | 0.72 | 21.5 | 7.6 | 1.17 | .277 | 3.60 | 7.74 |
| 23 | | D. Gooden | 2,293 | 430 | 194 | 112 | .634 | 410 | 3.51 | 68 | 24 | 3 | 2800.2 | 2,564 | 1,091 | 1,198 | 210 | 954 | 78 | 4 | 42 | 11,705 | 76 | 7.37 | 3.07 | 2.40 | 0.67 | 19.6 | 8.2 | 1.26 | .288 | 3.85 | 8.24 |
| 24 | | M. Lolich | 2,272 | 460 | 175 | 163 | .518 | 402 | 3.45 | 170 | 31 | 5 | 2979.1 | 2,780 | 1,141 | 1,267 | 281 | 890 | 69 | 25 | 64 | 12,395 | 99 | 6.86 | 2.69 | 2.55 | 0.85 | 18.3 | 7.2 | 1.23 | .281 | 3.83 | 8.40 |
| 25 | | K. Brown | 2,258 | 449 | 197 | 130 | .602 | 439 | 3.16 | 72 | 17 | 0 | 3039.0 | 2,828 | 1,068 | 1,229 | 189 | 840 | 129 | 1 | 40 | 12,592 | 95 | 6.69 | 2.49 | 2.69 | 0.56 | 17.9 | 6.7 | 1.21 | .288 | 3.64 | 8.38 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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89 | 63 | .586 | ||
83 | 68 | .550 | 5.5 | |
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| NL Central | W | L | PCT | GB |
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