Between May 31, 1967 and August 27, 2003, Nolan Ryan struck out the most batters, with 5,708 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,708 | 805 | 324 | 291 | .527 | 772 | 3.19 | 222 | 61 | 3 | 5383.0 | 3,918 | 1,906 | 2,173 | 320 | 2,792 | 158 | 13 | 77 | 22,558 | 276 | 9.54 | 4.67 | 2.04 | 0.54 | 25.3 | 12.4 | 1.25 | .265 | 3.63 | 6.55 |
| 2 |  | R. Clemens | 4,078 | 601 | 305 | 159 | .657 | 600 | 3.19 | 117 | 46 | 0 | 4242.0 | 3,643 | 1,502 | 1,654 | 318 | 1,369 | 140 | 0 | 52 | 17,503 | 125 | 8.65 | 2.90 | 2.98 | 0.67 | 23.3 | 7.8 | 1.18 | .287 | 3.51 | 7.73 |
| 3 |  | S. Carlton | 4,058 | 710 | 323 | 240 | .574 | 693 | 3.22 | 251 | 54 | 1 | 5104.2 | 4,554 | 1,827 | 2,087 | 406 | 1,799 | 52 | 7 | 148 | 21,209 | 174 | 7.15 | 3.17 | 2.26 | 0.72 | 19.1 | 8.5 | 1.24 | .279 | 3.68 | 8.03 |
| 4 |  | R. Johnson | 3,823 | 448 | 228 | 112 | .671 | 438 | 3.11 | 87 | 34 | 2 | 3081.1 | 2,394 | 1,064 | 1,201 | 278 | 1,248 | 144 | 5 | 21 | 12,728 | 92 | 11.17 | 3.65 | 3.06 | 0.81 | 30.0 | 9.8 | 1.18 | .292 | 3.51 | 6.99 |
| 5 |  | B. Blyleven | 3,701 | 692 | 287 | 250 | .534 | 685 | 3.31 | 242 | 60 | 0 | 4970.0 | 4,632 | 1,830 | 2,029 | 430 | 1,322 | 155 | 3 | 71 | 20,492 | 114 | 6.70 | 2.39 | 2.80 | 0.78 | 18.1 | 6.5 | 1.20 | .282 | 3.67 | 8.39 |
| 6 |  | T. Seaver | 3,600 | 647 | 307 | 203 | .602 | 638 | 2.87 | 227 | 61 | 1 | 4719.1 | 3,913 | 1,503 | 1,654 | 373 | 1,373 | 74 | 6 | 117 | 19,109 | 122 | 6.87 | 2.62 | 2.62 | 0.71 | 18.8 | 7.2 | 1.12 | .259 | 3.15 | 7.46 |
| 7 | | D. Sutton | 3,317 | 726 | 310 | 238 | .566 | 710 | 3.26 | 170 | 55 | 5 | 4985.2 | 4,428 | 1,804 | 1,983 | 447 | 1,270 | 76 | 12 | 97 | 20,416 | 107 | 5.99 | 2.29 | 2.61 | 0.81 | 16.2 | 6.2 | 1.14 | .260 | 3.58 | 7.99 |
| 8 | | P. Niekro | 3,244 | 765 | 311 | 266 | .539 | 715 | 3.36 | 245 | 45 | 15 | 5225.0 | 4,875 | 1,949 | 2,250 | 470 | 1,739 | 116 | 34 | 77 | 21,901 | 212 | 5.59 | 3.00 | 1.87 | 0.81 | 14.8 | 7.9 | 1.27 | .270 | 3.88 | 8.40 |
| 9 | | F. Jenkins | 2,975 | 585 | 271 | 214 | .559 | 571 | 3.34 | 260 | 47 | 1 | 4230.1 | 3,924 | 1,570 | 1,745 | 451 | 916 | 79 | 9 | 102 | 17,305 | 60 | 6.33 | 1.95 | 3.25 | 0.96 | 17.2 | 5.3 | 1.14 | .270 | 3.71 | 8.35 |
| 10 | | G. Perry | 2,876 | 595 | 266 | 223 | .544 | 588 | 3.05 | 274 | 47 | 3 | 4492.1 | 4,112 | 1,520 | 1,766 | 326 | 1,169 | 89 | 7 | 128 | 18,378 | 127 | 5.76 | 2.34 | 2.46 | 0.65 | 15.6 | 6.4 | 1.18 | .272 | 3.54 | 8.24 |
| 11 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 12 |  | G. Maddux | 2,750 | 569 | 286 | 162 | .638 | 565 | 2.89 | 103 | 34 | 0 | 3934.2 | 3,589 | 1,263 | 1,446 | 233 | 835 | 108 | 3 | 153 | 15,979 | 52 | 6.29 | 1.91 | 3.29 | 0.53 | 17.2 | 5.2 | 1.12 | .278 | 3.31 | 8.21 |
| 13 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 14 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 15 | | J. Koosman | 2,553 | 607 | 222 | 209 | .515 | 527 | 3.36 | 140 | 33 | 17 | 3830.0 | 3,626 | 1,428 | 1,601 | 289 | 1,190 | 71 | 42 | 118 | 15,950 | 89 | 6.00 | 2.80 | 2.15 | 0.68 | 16.0 | 7.5 | 1.26 | .282 | 3.76 | 8.52 |
| 16 | | C. Schilling | 2,514 | 446 | 162 | 116 | .583 | 334 | 3.33 | 79 | 19 | 13 | 2560.0 | 2,259 | 946 | 1,006 | 260 | 598 | 39 | 60 | 40 | 10,383 | 67 | 8.84 | 2.10 | 4.20 | 0.91 | 24.2 | 5.8 | 1.12 | .287 | 3.54 | 7.94 |
| 17 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 18 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 19 | | D. Eckersley | 2,401 | 1,071 | 197 | 171 | .535 | 361 | 3.50 | 100 | 20 | 390 | 3285.2 | 3,076 | 1,279 | 1,382 | 347 | 738 | 75 | 577 | 90 | 13,534 | 28 | 6.58 | 2.02 | 3.25 | 0.95 | 17.7 | 5.5 | 1.16 | .274 | 3.79 | 8.43 |
| 20 |  | P. Martinez | 2,386 | 349 | 162 | 66 | .711 | 282 | 2.60 | 40 | 15 | 3 | 2042.0 | 1,525 | 589 | 659 | 148 | 548 | 97 | 23 | 21 | 8,141 | 51 | 10.52 | 2.42 | 4.35 | 0.65 | 29.3 | 6.7 | 1.02 | .278 | 2.90 | 6.72 |
| 21 | | C. Hough | 2,362 | 858 | 216 | 216 | .500 | 440 | 3.75 | 107 | 13 | 61 | 3801.1 | 3,283 | 1,582 | 1,807 | 383 | 1,664 | 174 | 240 | 44 | 16,168 | 180 | 5.59 | 3.94 | 1.42 | 0.91 | 14.6 | 10.3 | 1.30 | .250 | 4.28 | 7.77 |
| 22 |  | J. Smoltz | 2,307 | 525 | 163 | 120 | .576 | 361 | 3.29 | 47 | 14 | 109 | 2614.2 | 2,249 | 955 | 1,047 | 208 | 816 | 40 | 141 | 59 | 10,730 | 122 | 7.94 | 2.81 | 2.83 | 0.72 | 21.5 | 7.6 | 1.17 | .277 | 3.60 | 7.74 |
| 23 | | D. Gooden | 2,293 | 430 | 194 | 112 | .634 | 410 | 3.51 | 68 | 24 | 3 | 2800.2 | 2,564 | 1,091 | 1,198 | 210 | 954 | 78 | 4 | 42 | 11,705 | 76 | 7.37 | 3.07 | 2.40 | 0.67 | 19.6 | 8.2 | 1.26 | .288 | 3.85 | 8.24 |
| 24 | | K. Brown | 2,230 | 445 | 195 | 129 | .602 | 435 | 3.16 | 72 | 17 | 0 | 3012.0 | 2,809 | 1,057 | 1,218 | 186 | 832 | 128 | 1 | 40 | 12,489 | 95 | 6.66 | 2.49 | 2.68 | 0.56 | 17.9 | 6.7 | 1.21 | .288 | 3.64 | 8.39 |
| 25 | | V. Blue | 2,175 | 502 | 209 | 161 | .565 | 473 | 3.27 | 143 | 37 | 2 | 3343.1 | 2,939 | 1,213 | 1,357 | 263 | 1,185 | 23 | 11 | 61 | 13,838 | 103 | 5.85 | 3.19 | 1.84 | 0.71 | 15.7 | 8.6 | 1.23 | .263 | 3.65 | 7.91 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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