Between September 22, 1957 and August 19, 2000, Nolan Ryan struck out the most hitters, with 5,714 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,714 | 807 | 324 | 292 | .526 | 773 | 3.19 | 222 | 61 | 3 | 5386.0 | 3,923 | 1,911 | 2,178 | 321 | 2,795 | 158 | 13 | 78 | 22,575 | 277 | 9.55 | 4.67 | 2.04 | 0.54 | 25.3 | 12.4 | 1.25 | .265 | 3.64 | 6.56 |
| 2 |  | S. Carlton | 4,136 | 741 | 329 | 244 | .574 | 709 | 3.22 | 254 | 55 | 2 | 5217.2 | 4,672 | 1,864 | 2,130 | 414 | 1,833 | 53 | 13 | 150 | 21,682 | 183 | 7.13 | 3.16 | 2.26 | 0.71 | 19.1 | 8.5 | 1.25 | .279 | 3.67 | 8.06 |
| 3 |  | B. Blyleven | 3,701 | 692 | 287 | 250 | .534 | 685 | 3.31 | 242 | 60 | 0 | 4970.0 | 4,632 | 1,830 | 2,029 | 430 | 1,322 | 155 | 3 | 71 | 20,492 | 114 | 6.70 | 2.39 | 2.80 | 0.78 | 18.1 | 6.5 | 1.20 | .282 | 3.67 | 8.39 |
| 4 |  | T. Seaver | 3,640 | 656 | 311 | 205 | .603 | 647 | 2.86 | 231 | 61 | 1 | 4783.0 | 3,971 | 1,521 | 1,674 | 380 | 1,390 | 76 | 6 | 117 | 19,369 | 125 | 6.85 | 2.62 | 2.62 | 0.72 | 18.8 | 7.2 | 1.12 | .259 | 3.15 | 7.47 |
| 5 | | D. Sutton | 3,574 | 774 | 324 | 256 | .559 | 756 | 3.26 | 178 | 58 | 5 | 5282.1 | 4,692 | 1,914 | 2,104 | 472 | 1,343 | 82 | 12 | 103 | 21,631 | 112 | 6.09 | 2.29 | 2.66 | 0.80 | 16.5 | 6.2 | 1.14 | .261 | 3.58 | 7.99 |
| 6 | | G. Perry | 3,534 | 777 | 314 | 265 | .542 | 690 | 3.11 | 303 | 53 | 10 | 5350.0 | 4,938 | 1,846 | 2,128 | 399 | 1,378 | 108 | 33 | 163 | 21,953 | 160 | 5.95 | 2.32 | 2.56 | 0.67 | 16.1 | 6.3 | 1.18 | .275 | 3.58 | 8.31 |
| 7 |  | R. Clemens | 3,450 | 504 | 257 | 140 | .647 | 503 | 3.07 | 116 | 45 | 0 | 3614.2 | 3,056 | 1,231 | 1,364 | 252 | 1,166 | 122 | 0 | 44 | 14,872 | 92 | 8.59 | 2.90 | 2.96 | 0.63 | 23.2 | 7.8 | 1.17 | .284 | 3.40 | 7.61 |
| 8 | | P. Niekro | 3,342 | 864 | 318 | 274 | .537 | 716 | 3.35 | 245 | 45 | 29 | 5404.0 | 5,044 | 2,012 | 2,337 | 482 | 1,809 | 123 | 83 | 86 | 22,677 | 227 | 5.57 | 3.01 | 1.85 | 0.80 | 14.7 | 8.0 | 1.27 | .270 | 3.89 | 8.40 |
| 9 | | F. Jenkins | 3,191 | 664 | 284 | 226 | .557 | 594 | 3.34 | 267 | 49 | 7 | 4500.2 | 4,142 | 1,669 | 1,853 | 484 | 997 | 84 | 37 | 117 | 18,404 | 62 | 6.38 | 1.99 | 3.20 | 0.97 | 17.3 | 5.4 | 1.14 | .268 | 3.71 | 8.28 |
| 10 |  | B. Gibson | 3,117 | 528 | 251 | 174 | .591 | 482 | 2.91 | 255 | 56 | 6 | 3884.1 | 3,279 | 1,258 | 1,420 | 257 | 1,336 | 102 | 21 | 118 | 16,066 | 109 | 7.22 | 3.10 | 2.33 | 0.60 | 19.4 | 8.3 | 1.19 | .269 | 3.29 | 7.60 |
| 11 |  | R. Johnson | 2,958 | 357 | 175 | 92 | .655 | 348 | 3.18 | 74 | 27 | 2 | 2440.1 | 1,876 | 861 | 970 | 215 | 1,068 | 105 | 4 | 16 | 10,134 | 79 | 10.91 | 3.94 | 2.77 | 0.79 | 29.2 | 10.5 | 1.21 | .287 | 3.58 | 6.92 |
| 12 | | M. Lolich | 2,832 | 586 | 217 | 191 | .532 | 496 | 3.44 | 195 | 41 | 10 | 3638.1 | 3,366 | 1,390 | 1,537 | 347 | 1,099 | 91 | 40 | 67 | 15,139 | 123 | 7.01 | 2.72 | 2.58 | 0.86 | 18.7 | 7.3 | 1.23 | .280 | 3.80 | 8.33 |
| 13 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 14 | | J. Bunning | 2,615 | 519 | 197 | 170 | .537 | 480 | 3.27 | 137 | 39 | 13 | 3405.0 | 3,122 | 1,239 | 1,385 | 329 | 872 | 146 | 27 | 88 | 14,122 | 39 | 6.91 | 2.30 | 3.00 | 0.87 | 18.5 | 6.2 | 1.17 | .275 | 3.66 | 8.25 |
| 15 | | J. Koosman | 2,556 | 612 | 222 | 209 | .515 | 527 | 3.36 | 140 | 33 | 17 | 3839.1 | 3,635 | 1,433 | 1,608 | 290 | 1,198 | 71 | 43 | 121 | 15,996 | 89 | 5.99 | 2.81 | 2.13 | 0.68 | 16.0 | 7.5 | 1.26 | .282 | 3.77 | 8.52 |
| 16 | | D. Cone | 2,513 | 412 | 183 | 112 | .620 | 383 | 3.34 | 56 | 22 | 1 | 2713.0 | 2,295 | 1,007 | 1,104 | 234 | 1,044 | 92 | 9 | 36 | 11,324 | 138 | 8.34 | 3.46 | 2.41 | 0.78 | 22.2 | 9.2 | 1.23 | .277 | 3.66 | 7.61 |
| 17 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 18 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 19 | | J. Kaat | 2,462 | 898 | 283 | 237 | .544 | 625 | 3.45 | 180 | 31 | 17 | 4530.0 | 4,620 | 1,738 | 2,038 | 395 | 1,083 | 122 | 102 | 117 | 19,026 | 128 | 4.89 | 2.15 | 2.27 | 0.78 | 12.9 | 5.7 | 1.26 | .282 | 4.05 | 9.18 |
| 20 | | S. McDowell | 2,453 | 425 | 141 | 134 | .513 | 346 | 3.17 | 103 | 23 | 14 | 2492.1 | 1,948 | 879 | 999 | 164 | 1,312 | 59 | 39 | 73 | 10,589 | 141 | 8.86 | 4.74 | 1.87 | 0.59 | 23.2 | 12.4 | 1.31 | .270 | 3.61 | 7.03 |
| 21 | | L. Tiant | 2,416 | 573 | 229 | 172 | .571 | 484 | 3.30 | 187 | 49 | 15 | 3486.1 | 3,075 | 1,280 | 1,400 | 346 | 1,104 | 49 | 51 | 53 | 14,366 | 27 | 6.24 | 2.85 | 2.19 | 0.89 | 16.8 | 7.7 | 1.20 | .261 | 3.61 | 7.94 |
| 22 | | D. Eckersley | 2,401 | 1,071 | 197 | 171 | .535 | 361 | 3.50 | 100 | 20 | 390 | 3285.2 | 3,076 | 1,279 | 1,382 | 347 | 738 | 75 | 577 | 90 | 13,534 | 28 | 6.58 | 2.02 | 3.25 | 0.95 | 17.7 | 5.5 | 1.16 | .274 | 3.79 | 8.43 |
| 23 | | C. Hough | 2,362 | 858 | 216 | 216 | .500 | 440 | 3.75 | 107 | 13 | 61 | 3801.1 | 3,283 | 1,582 | 1,807 | 383 | 1,664 | 174 | 240 | 44 | 16,168 | 180 | 5.59 | 3.94 | 1.42 | 0.91 | 14.6 | 10.3 | 1.30 | .250 | 4.28 | 7.77 |
| 24 |  | G. Maddux | 2,306 | 463 | 234 | 133 | .638 | 459 | 2.83 | 97 | 29 | 0 | 3258.2 | 2,941 | 1,025 | 1,178 | 173 | 727 | 87 | 3 | 128 | 13,239 | 47 | 6.37 | 2.01 | 3.17 | 0.48 | 17.4 | 5.5 | 1.13 | .278 | 3.25 | 8.12 |
| 25 | | J. Marichal | 2,302 | 471 | 243 | 142 | .631 | 457 | 2.89 | 244 | 52 | 2 | 3507.0 | 3,153 | 1,126 | 1,329 | 320 | 709 | 40 | 11 | 82 | 14,237 | 51 | 5.91 | 1.82 | 3.25 | 0.82 | 16.2 | 5.0 | 1.10 | .261 | 3.41 | 8.09 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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