most strikeouts per game by a pitcher all-time with a min of 350 games played

Randy Johnson has the most career strikeouts per game pitched when pitching in 350+ games, with 7.89.

	NAME	SO/G	G	SO	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Randy Johnson R. Johnson	7.89	618	4,875	303	166	.646	603	3.29	100	37	2	4135.1	3,346	1,513	1,703	411	1,497	190	7	37	17,067	109	10.61	3.26	3.26	0.89	28.6	8.8	1.17	.291	3.71	75	3.18	73	7.28	554.3
2	Max Scherzer M. Scherzer	7.22	483	3,489	220	117	.653	474	3.22	12	5	0	2963.0	2,433	1,059	1,132	354	779	114	2	20	11,987	80	10.60	2.37	4.48	1.08	29.1	6.5	1.08	.287	3.44	77	3.23	78	7.39	302.5
3	Nolan Ryan N. Ryan	7.08	807	5,714	324	292	.526	773	3.19	222	61	3	5386.0	3,923	1,911	2,178	321	2,795	158	13	78	22,575	277	9.55	4.67	2.04	0.54	25.3	12.4	1.25	.265	3.64	90	2.96	83	6.56	370.2
4	Clayton Kershaw C. Kershaw	6.71	455	3,052	223	96	.699	451	2.53	25	15	0	2855.1	2,193	804	881	235	713	46	1	28	11,279	108	9.62	2.25	4.28	0.74	27.1	6.3	1.02	.271	2.78	65	2.85	70	6.91	375.1
5	Pedro Martinez P. Martinez	6.63	476	3,154	219	100	.687	409	2.93	46	17	3	2827.1	2,221	919	1,006	239	760	141	23	30	11,394	62	10.04	2.42	4.15	0.76	27.7	6.7	1.05	.279	3.20	66	2.91	68	7.07	454.6
6	Roger Clemens R. Clemens	6.59	709	4,672	354	184	.658	707	3.12	118	46	0	4916.2	4,185	1,707	1,885	363	1,580	159	0	63	20,240	143	8.55	2.89	2.96	0.66	23.1	7.8	1.17	.284	3.45	70	3.08	71	7.66	680.4
7	Chris Sale C. Sale	6.56	393	2,579	145	88	.622	312	3.01	16	3	12	2084.0	1,692	697	750	213	487	130	25	15	8,389	48	11.14	2.10	5.30	0.92	30.7	5.8	1.05	.297	3.24	70	2.87	68	7.31	303.3
8	Justin Verlander J. Verlander	6.4	555	3,553	266	158	.627	555	3.32	26	9	0	3567.2	3,046	1,317	1,428	371	1,004	121	0	28	14,607	99	8.96	2.53	3.54	0.94	24.3	6.9	1.14	.280	3.60	79	3.43	81	7.68	310.9
9	Cole Hamels C. Hamels	6.05	423	2,560	163	122	.572	422	3.43	17	7	0	2698.0	2,424	1,027	1,103	310	767	100	0	43	11,115	57	8.54	2.56	3.34	1.03	23.0	6.9	1.18	.287	3.68	82	3.68	88	8.09	151.3
10	Sandy Koufax S. Koufax	6.04	397	2,396	165	87	.655	314	2.76	137	40	9	2324.1	1,754	713	806	204	817	18	44	48	9,497	87	9.28	3.16	2.93	0.79	25.2	8.6	1.11	.256	3.12	75	2.69	75	6.79	226.6
11	Felix Hernandez F. Hernandez	6.02	419	2,524	169	136	.554	418	3.42	25	11	0	2729.2	2,487	1,037	1,157	264	805	105	0	16	11,284	156	8.32	2.65	3.14	0.87	22.4	7.1	1.21	.293	3.81	84	3.52	85	8.20	181.5
12	David Cone D. Cone	5.93	450	2,668	194	126	.606	419	3.46	56	22	1	2898.2	2,504	1,115	1,222	258	1,137	106	9	42	12,184	149	8.28	3.53	2.35	0.80	21.9	9.3	1.26	.280	3.79	84	3.56	85	7.77	190.9
13	Bob Gibson B. Gibson	5.9	528	3,117	251	174	.591	482	2.91	255	56	6	3884.1	3,279	1,258	1,420	257	1,336	102	21	118	16,068	108	7.22	3.10	2.33	0.60	19.4	8.3	1.19	.268	3.29	78	2.89	81	7.60	290.5
14	Madison Bumgarner M. Bumgarner	5.78	358	2,070	134	124	.519	355	3.47	16	7	0	2209.1	2,007	853	933	258	544	89	1	38	9,098	29	8.43	2.22	3.81	1.05	22.8	6.0	1.15	.285	3.80	90	3.62	94	8.18	50.1
15	A.J. Burnett	5.78	435	2,513	164	157	.511	430	3.99	24	10	0	2731.1	2,519	1,210	1,328	263	1,100	143	1	35	11,665	161	8.28	3.62	2.28	0.87	21.5	9.4	1.32	.295	4.38	97	3.86	92	8.30	97.3
16	Sam McDowell S. McDowell	5.77	425	2,453	141	134	.513	346	3.17	103	23	14	2492.1	1,948	879	999	164	1,312	59	39	74	10,587	140	8.86	4.74	1.87	0.59	23.2	12.4	1.31	.270	3.61	90	3.06	84	7.03	160.4
17	Rube Waddell R. Waddell	5.69	407	2,316	193	143	.574	340	2.16	261	50	5	2961.1	2,460	711	1,063	37	803	115	54		11,717	74	7.04	2.44	2.88	0.11	19.8	6.9	1.10	.287	3.23	75	2.03	71	7.48	262
18	Jake Peavy J. Peavy	5.69	388	2,207	152	126	.547	377	3.63	15	6	0	2377.0	2,134	960	1,011	259	708	78	3	42	9,838	46	8.36	2.68	3.12	0.98	22.4	7.2	1.20	.285	3.83	90	3.64	89	8.08	127.6
19	Javier Vazquez J. Vazquez	5.64	450	2,536	165	160	.508	443	4.22	28	8	0	2840.0	2,784	1,331	1,431	373	763	88	5	58	11,935	76	8.04	2.42	3.32	1.18	21.2	6.4	1.25	.295	4.53	96	3.90	88	8.82	164.4
20	Steve Carlton S. Carlton	5.58	741	4,136	329	244	.574	709	3.22	254	55	2	5217.2	4,672	1,864	2,130	414	1,833	53	13	150	21,683	183	7.13	3.16	2.26	0.71	19.1	8.5	1.25	.279	3.67	87	3.14	86	8.06	271.5
21	Tom Seaver T. Seaver	5.55	656	3,640	311	205	.603	647	2.86	231	61	1	4783.0	3,971	1,521	1,674	380	1,390	76	6	116	19,369	126	6.85	2.62	2.62	0.72	18.8	7.2	1.12	.259	3.15	79	3.03	85	7.47	286.1
22	Lance Lynn L. Lynn	5.54	364	2,015	143	99	.591	340	3.74	4	2	1	2006.1	1,856	834	916	231	704	89	4	21	8,520	61	9.04	3.16	2.86	1.04	23.7	8.3	1.28	.296	4.11	91	3.82	93	8.33	67.8
23	Johan Santana J. Santana	5.52	360	1,988	139	78	.641	284	3.20	15	10	1	2025.2	1,726	721	773	220	567	36	23	13	8,262	68	8.83	2.52	3.51	0.98	24.1	6.9	1.13	.276	3.43	74	3.43	81	7.67	187.6
24	CC Sabathia	5.51	561	3,093	251	161	.609	560	3.74	38	12	0	3577.1	3,404	1,485	1,623	382	1,099	123	0	44	14,989	74	7.78	2.76	2.81	0.96	20.6	7.3	1.26	.294	4.08	87	3.77	87	8.56	223.7
25	Jon Lester J. Lester	5.5	452	2,488	200	117	.631	451	3.66	15	4	0	2740.0	2,610	1,114	1,215	294	892	90	0	13	11,487	63	8.17	2.93	2.79	0.97	21.7	7.8	1.28	.300	3.99	86	3.77	92	8.57	101.7