Before May 21, 1966, Mickey Mantle had the most strikeouts, with 1,447 strikeouts.

Interpreted as:

most strikeouts by a player through may 20, 1966

	NAME	SO	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Mickey Mantle M. Mantle	1,447	2,030	6,967	1,521	2,127	306	70	475	1,352	1,474	10	145	38	8,500	3,998	851	13	36	107	88	.305	.425	.574	.999
2	Eddie Mathews E. Mathews	1,332	2,121	7,705	1,392	2,107	321	66	479	1,342	1,328	23	67	36	9,139	3,997	866	32	51	88	117	.273	.380	.519	.898
3	Jimmie Foxx J. Foxx	1,311	2,317	8,134	1,751	2,645	458	125	534	1,924	1,457	13	87		9,676	4,955	1,117	72			70	.325	.428	.609	1.038
4	Babe Ruth B. Ruth	1,304	2,457	8,298	2,156	2,842	495	135	710	2,193	2,053	44	123		10,509	5,737	1,340	114				.342	.475	.691	1.167
5	Duke Snider D. Snider	1,236	2,143	7,161	1,259	2,116	358	85	407	1,333	971	21	99	50	8,237	3,865	850	52	32	104	165	.295	.380	.540	.919
6	Gil Hodges G. Hodges	1,137	2,072	7,029	1,105	1,921	295	48	370	1,274	943	25	63	31	8,102	3,422	713	55	50	31	165	.273	.359	.487	.846
7	Joe Adcock J. Adcock	1,021	1,890	6,411	796	1,782	288	33	321	1,082	568	17	19	24	7,081	3,099	642	52	33	50	216	.278	.337	.483	.820
8	Larry Doby L. Doby	1,012	1,533	5,348	960	1,515	243	52	253	972	869	38	47	15	6,300	2,621	548	20	25	19	100	.283	.386	.490	.876
9	Dolph Camilli D. Camilli	964	1,489	5,353	936	1,482	261	86	239	952	947	28	60		6,352	2,632	586	24			45	.277	.388	.492	.880
10	Eddie Yost E. Yost	921	2,109	7,345	1,215	1,863	337	56	139	683	1,614	99	72	50	9,174	2,729	532	98	18	14	137	.254	.394	.372	.766
11	Willie Mays W. Mays	916	2,039	7,722	1,518	2,415	381	118	515	1,426	969	27	279	86	8,786	4,577	1,014	4	64	143	179	.313	.388	.593	.981
12	Roy Sievers R. Sievers	916	1,887	6,386	944	1,703	292	42	318	1,147	840	51	14	16	7,347	3,033	652	15	55	57	164	.267	.354	.475	.829
13	Dick Stuart D. Stuart	903	1,031	3,797	493	1,010	154	30	221	721	281	20	2	6	4,141	1,887	405	6	37	31	110	.266	.317	.497	.814
14	Harmon Killebrew H. Killebrew	903	1,136	3,926	660	1,025	137	14	299	753	651	31	6	8	4,638	2,087	450	0	30	41	96	.261	.368	.532	.900
15	Frank Thomas F. Thomas	895	1,763	6,281	793	1,671	263	31	286	961	484	51	15	24	6,912	2,854	580	26	70	55	192	.266	.320	.454	.775
16	Mel Ott M. Ott	895	2,730	9,455	1,859	2,876	488	72	511	1,865	1,720	64	89		11,348	5,041	1,071	109			38	.304	.415	.533	.948
17	Pee Wee Reese P. Wee Reese	890	2,166	8,058	1,338	2,169	330	80	126	885	1,211	26	232	45	9,470	3,037	536	155	20	3	176	.269	.366	.377	.743
18	Ernie Banks E. Banks	881	1,844	6,996	1,032	1,952	307	76	406	1,230	616	50	45	51	7,750	3,629	789	13	75	164	165	.279	.338	.519	.857
19	Mickey Vernon M. Vernon	870	2,409	8,732	1,196	2,496	491	120	172	1,312	958	49	137	33	9,838	3,743	783	80	19	21	184	.286	.359	.429	.788
20	Ken Boyer K. Boyer	869	1,688	6,418	1,000	1,879	274	61	258	1,016	635	19	98	72	7,136	3,049	593	14	50	89	157	.293	.356	.475	.831
21	Rudy York R. York	869	1,603	5,891	875	1,621	291	52	277	1,150	795	12	38		6,723	2,847	620	25			155	.275	.362	.483	.846
22	Tony Lazzeri T. Lazzeri	866	1,740	6,299	986	1,840	334	115	178	1,198	877	22	148		7,313	2,938	627	115			3	.292	.381	.466	.847
23	Jimmy Dykes J. Dykes	852	2,283	8,048	1,107	2,256	453	90	108		959	115	70		9,350	3,213	651	228			0	.280	.365	.399	.764
24	Bob Johnson B. Johnson	851	1,863	6,920	1,239	2,051	396	95	288	1,283	1,077	24	96		8,049	3,501	779	28			102	.296	.393	.506	.899
25	Hank Greenberg H. Greenberg	844	1,394	5,194	1,047	1,628	379	71	331	1,273	853	16	58		6,098	3,142	781	35			66	.313	.412	.605	1.017