The San Diego Padres are 294-321 against the Astros all-time.

	OPP	REC	W%	G	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Astros	294-321	.478	615	294	321	20,766	2,400	5,125	846	125	386	2,261	1,920	154	3,852	449	187	23,269	7,379	1,357	269	160	187	411	.247	.313	.355	.668
2	Giants	455-496	.478	951	455	496	32,425	3,902	8,123	1,378	212	779	3,665	3,028	220	6,166	640	278	36,329	12,262	2,369	403	253	310	702	.251	.317	.378	.695
3	Dodgers	429-528	.448	958	429	528	32,003	3,423	7,513	1,292	123	695	3,201	2,932	210	6,876	654	279	35,815	11,136	2,110	433	237	306	665	.235	.301	.348	.649
4	Braves	297-371	.445	668	297	371	22,702	2,632	5,729	933	130	501	2,459	2,005	122	4,107	550	210	25,337	8,425	1,564	347	161	224	490	.252	.314	.371	.685
5	Reds	310-350	.470	661	310	350	22,302	2,680	5,586	1,030	131	509	2,517	2,191	132	4,094	419	185	25,108	8,405	1,670	313	170	235	491	.250	.319	.377	.696
6	Pirates	245-275	.471	520	245	275	17,686	2,135	4,463	783	112	399	2,014	1,738	123	3,260	345	188	19,933	6,667	1,294	250	136	176	392	.252	.321	.377	.698
7	Cardinals	217-305	.416	522	217	305	17,467	1,953	4,360	773	120	354	1,831	1,578	104	3,047	293	162	19,521	6,435	1,247	252	120	183	421	.250	.314	.368	.682
8	Cubs	239-285	.456	524	239	285	17,642	2,114	4,401	738	105	437	1,987	1,710	119	3,384	342	169	19,856	6,660	1,280	241	144	188	378	.249	.318	.378	.695
9	Mets	265-259	.506	524	265	259	17,509	2,003	4,303	737	94	408	1,869	1,623	107	3,623	366	163	19,600	6,452	1,239	240	121	165	385	.246	.312	.368	.680
10	Nationals	250-269	.482	519	250	269	17,629	2,096	4,386	697	111	436	1,978	1,666	126	3,351	411	169	19,783	6,613	1,244	244	118	150	348	.249	.316	.375	.691
11	Phillies	229-292	.440	521	229	292	17,753	2,134	4,499	850	131	400	1,991	1,706	107	3,362	352	146	19,886	6,811	1,381	191	129	152	379	.253	.320	.384	.704
12	Marlins	121-108	.528	229	121	108	7,676	985	1,918	377	53	178	923	842	74	1,677	155	75	8,753	2,935	608	89	72	67	156	.250	.327	.382	.709
13	Rockies	258-276	.483	534	258	276	18,307	2,695	4,928	1,005	127	590	2,565	1,905	173	3,696	322	111	20,703	7,957	1,722	162	156	120	484	.269	.341	.435	.776
14	Angels	23-25	.479	48	23	25	1,642	198	396	79	8	39	180	178	18	374	32	16	1,867	608	126	16	13	15	26	.241	.320	.370	.690
15	Rangers	32-25	.561	57	32	25	1,955	254	535	96	9	49	242	182	16	394	35	15	2,178	796	154	10	15	9	49	.274	.338	.407	.745
16	Athletics	22-27	.449	49	22	27	1,691	225	442	74	6	55	208	173	14	383	32	15	1,899	693	135	11	10	12	38	.261	.333	.410	.743
17	Mariners	63-71	.470	134	63	71	4,445	524	1,054	197	20	130	496	411	36	1,018	78	32	4,950	1,681	347	32	26	22	79	.237	.305	.378	.683
18	Diamondbacks	230-247	.482	477	230	247	16,050	2,055	3,945	773	88	509	1,955	1,528	150	3,748	262	112	17,964	6,421	1,370	118	118	85	324	.246	.315	.400	.715
19	Brewers	93-90	.508	183	93	90	6,250	822	1,623	270	35	189	778	655	41	1,427	143	40	7,050	2,530	494	58	46	46	149	.260	.332	.405	.736
20	Rays	11-19	.367	30	11	19	991	122	231	45	2	31	115	113	12	248	23	9	1,130	373	78	5	9	7	22	.233	.316	.376	.693
21	Orioles	14-13	.519	27	14	13	944	153	267	50	4	40	144	85	14	204	24	7	1,051	445	94	6	2	3	25	.283	.350	.471	.822
22	Red Sox	12-18	.400	30	12	18	979	100	219	46	2	22	97	97	14	229	16	6	1,101	335	70	8	3	2	13	.224	.302	.342	.644
23	Yankees	10-17	.370	27	10	17	899	96	205	39	2	21	91	90	11	240	18	5	1,011	311	62	2	9	4	10	.228	.303	.346	.649
24	Royals	16-11	.593	27	16	11	930	141	268	46	5	29	134	105	6	199	5	10	1,056	411	80	5	10	8	25	.288	.361	.442	.803
25	Tigers	12-15	.444	27	12	15	883	108	210	42	6	24	105	91	10	187	11	6	999	336	72	10	5	5	25	.238	.314	.381	.695