Warren Spahn has given up the most career home runs by a pitcher against a team, with 100 HR versus the Giants.

	NAME	HR	OPP	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Warren Spahn W. Spahn	100	Giants	119	56	43	.566	108	3.24	416	67	6	3	861.1	788	310	334	241	8	9		3,531	11	4.35	2.52	1.73	1.04	11.8	6.8	1.19	.249	3.49	8.23
2	Robin Roberts R. Roberts	95	Dodgers	95	29	45	.392	86	4.03	341	39	1	5	663.1	707	297	350	150	3	6		2,793	7	4.63	2.04	2.27	1.29	12.2	5.4	1.29	.278	4.75	9.59
3	Early Wynn E. Wynn	84	Yankees	113	33	58	.363	99	4.22	372	42	6	2	733.1	713	344	385	305	8	11	8	3,174	9	4.57	3.74	1.22	1.03	11.7	9.6	1.39	.262	4.73	8.75
4	Warren Spahn W. Spahn	68	Reds	113	62	29	.681	95	2.94	373	59	9	4	773.2	715	253	284	206	8	14	14	3,183	11	4.34	2.40	1.81	0.79	11.7	6.5	1.19	.256	3.30	8.32
5	Phil Niekro P. Niekro	64	Reds	87	29	34	.460	72	3.64	347	29	5	2	552.0	502	223	256	198	11	6	9	2,322	32	5.66	3.23	1.75	1.04	14.9	8.5	1.27	.257	4.17	8.18
6	Warren Spahn W. Spahn	63	Cardinals	125	64	41	.610	115	3.00	376	66	11	3	919.1	846	306	348	247	8	9		3,787	20	3.68	2.42	1.52	0.62	9.9	6.5	1.19	.253	3.41	8.28
7	Murry Dickson M. Dickson	62	Dodgers	81	18	28	.391	53	4.75	169	20	2	2	413.1	445	218	245	167	5	12		1,795	4	3.68	3.64	1.01	1.35	9.4	9.3	1.48	.275	5.33	9.69
8	Lew Burdette L. Burdette	61	Giants	76	32	17	.653	53	3.57	148	25	5	1	429.0	407	170	189	103	9	8		1,761	3	3.10	2.16	1.44	1.28	8.4	5.8	1.19	.240	3.97	8.54
9	Robin Roberts R. Roberts	60	Reds	75	35	24	.593	63	3.54	233	37	5	4	493.2	488	194	206	70	4	9		1,997	2	4.25	1.28	3.33	1.09	11.7	3.5	1.13	.263	3.76	8.90
10	Robin Roberts R. Roberts	58	Cardinals	80	39	28	.582	74	3.73	252	39	7	2	567.2	600	235	253	119	6	5		2,384	3	4.00	1.89	2.12	0.92	10.6	5.0	1.27	.278	4.01	9.51
11	Early Wynn E. Wynn	58	Red Sox	97	39	33	.542	84	3.90	376	40	7	3	630.0	620	273	310	274	9	11	10	2,750	13	5.37	3.91	1.37	0.83	13.7	10.0	1.42	.276	4.43	8.86
12	Earl Whitehill E. Whitehill	58	Yankees	84	29	34	.460	78	5.08	228	28	1	1	553.0	623	312	363	266	19	4		2,505	8	3.71	4.33	0.86	0.94	9.1	10.6	1.61	.292	5.91	10.14
13	Ted Lyons T. Lyons	58	Yankees	89	28	48	.368	78	4.78	195	48	5	0	619.0	723	329	394	203	10	8		2,746	5	2.84	2.95	0.96	0.84	7.1	7.4	1.50	.292	5.73	10.51
14	Frank Tanana F. Tanana	56	Athletics	59	23	25	.479	59	3.74	285	11	2	0	399.2	384	166	196	126	10	0	9	1,688	10	6.42	2.84	2.26	1.26	16.9	7.5	1.28	.271	4.41	8.65
15	Don Drysdale D. Drysdale	55	Braves	79	30	25	.545	71	3.03	404	25	6	0	531.1	458	179	211	139	27	3	23	2,197	8	6.84	2.35	2.91	0.93	18.4	6.3	1.12	.256	3.57	7.76
16	Rube Walberg R. Walberg	55	Yankees	104	20	26	.435	50	4.71	205	21	2	5	428.1	443	224	247	194	2	28		1,885	6	4.31	4.08	1.06	1.16	10.9	10.3	1.49	.272	5.19	9.31
17	Ed Lopat E. Lopat	54	Indians	63	40	13	.755	59	3.16	164	31	5	0	462.0	449	162	181	120	7	2	0	1,899	3	3.19	2.34	1.37	1.05	8.6	6.3	1.23	.254	3.53	8.75
18	Billy Pierce B. Pierce	53	Indians	88	37	29	.561	78	3.13	383	40	4	4	590.1	519	205	222	236	8	7	4	2,484	7	5.84	3.60	1.62	0.81	15.4	9.5	1.28	.258	3.38	7.91
19	Bob Lemon B. Lemon	53	Yankees	80	28	33	.459	59	4.66	187	19	3	4	429.0	432	222	261	220	8	13		1,927	4	3.92	4.62	0.85	1.11	9.7	11.4	1.52	.260	5.48	9.06
20	Red Ruffing R. Ruffing	53	Athletics	98	37	39	.487	84	3.95	317	49	7	3	662.1	653	291	336	229	11	9		2,823	7	4.31	3.11	1.38	0.72	11.2	8.1	1.33	.271	4.57	8.87
21	Bob Friend B. Friend	52	Braves	88	31	30	.508	74	3.61	238	22	5	2	530.2	528	213	245	131	8	11	11	2,220	5	4.04	2.22	1.82	0.88	10.7	5.9	1.24	.266	4.16	8.95
22	Robin Roberts R. Roberts	52	Braves	77	34	30	.531	73	3.38	291	44	5	1	562.2	533	211	226	115	7	2		2,294	3	4.65	1.84	2.53	0.83	12.7	5.0	1.15	.263	3.61	8.53
23	Mickey Lolich M. Lolich	51	Yankees	63	23	29	.442	55	3.60	287	25	4	2	402.1	391	161	187	107	9	4	10	1,689	14	6.42	2.39	2.68	1.14	17.0	6.3	1.24	.275	4.18	8.75
24	Camilo Pascual C. Pascual	51	Yankees	69	20	27	.426	56	3.98	296	18	6	1	391.2	370	173	188	147	3	7	12	1,669	13	6.80	3.38	2.01	1.17	17.7	8.8	1.32	.272	4.32	8.50
25	Robin Roberts R. Roberts	51	Pirates	79	40	25	.615	67	3.61	270	40	8	6	528.1	519	212	232	97	5	11		2,166	4	4.60	1.65	2.78	0.87	12.5	4.5	1.17	.269	3.95	8.84