Walter Johnson has pitched the most career innings by a pitcher against a team, with 920 innings versus the Tigers.

	NAME	IP	OPP	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Walter Johnson W. Johnson	920.0	Tigers	124	66	42	.611	105	1.88	521	79	12	5	798		346	11	276	32	19			25	5.10	2.70	1.89	0.11		7.5	1.17	.277	3.38	7.81
2	Warren Spahn W. Spahn	919.1	Cardinals	125	64	41	.610	115	3.00	376	66	11	3	846	306	348	63	247	8	9		3,787	20	3.68	2.42	1.52	0.62	9.9	6.5	1.19	.253	3.41	8.28
3	Walter Johnson W. Johnson	898.1	White Sox	125	63	39	.618	99	1.47	540	81	14	10	662		259	13	197	26	25			25	5.41	1.97	2.74	0.13		5.6	0.96	.238	2.59	6.63
4	Warren Spahn W. Spahn	861.1	Giants	119	56	43	.566	108	3.24	416	67	6	3	788	310	334	100	241	8	9		3,531	11	4.35	2.52	1.73	1.04	11.8	6.8	1.19	.249	3.49	8.23
5	Grover Alexander G. Alexander	847.0	Reds	108	70	24	.745	96	2.04	326	74	20	4	736		246	10	152	13	12			6	3.46	1.62	2.14	0.11		4.6	1.05	.257	2.61	7.82
6	Walter Johnson W. Johnson	846.1	Yankees	108	61	38	.616	94	1.61	521	78	21	3	687		261	23	209	30	14			31	5.54	2.22	2.49	0.24		6.2	1.06	.256	2.78	7.31
7	Walter Johnson W. Johnson	826.0	Athletics	112	59	39	.602	93	1.81	516	74	23	4	715		277	22	185	26	17			20	5.62	2.02	2.79	0.24		5.5	1.09	.266	3.02	7.79
8	Walter Johnson W. Johnson	815.0	Red Sox	112	53	43	.552	91	1.62	488	75	15	6	670		233	6	180	31	20			12	5.39	1.99	2.71	0.07		5.6	1.04	.262	2.57	7.40
9	Walter Johnson W. Johnson	809.1	Indians	109	59	41	.590	93	1.89	460	71	12	3	727		273	10	148	30	15			22	5.12	1.65	3.11	0.11		4.5	1.08	.275	3.04	8.08
10	Walter Johnson W. Johnson	801.2	Browns	112	56	37	.602	91	1.61	481	73	13	3	658		253	12	179	33	18			20	5.40	2.01	2.69	0.13		5.6	1.04	.260	2.84	7.39
11	Eddie Plank E. Plank	788.0	Tigers	106	60	31	.659	92	1.47	379	75	11	4	761		293	7	185	25	14			15	4.33	2.11	2.05	0.08		6.1	1.20	.307	3.35	8.69
12	Warren Spahn W. Spahn	773.2	Reds	113	62	29	.681	95	2.94	373	59	9	4	715	253	284	68	206	8	14	14	3,183	11	4.34	2.40	1.81	0.79	11.7	6.5	1.19	.256	3.30	8.32
13	Christy Mathewson C. Mathewson	770.0	Pirates	107	54	38	.587	89	1.04	378	63	8	6	712		296	17	125	11	17			22	4.42	1.46	3.02	0.20		4.1	1.09	.277	3.46	8.32
14	Grover Alexander G. Alexander	755.2	Braves	105	57	28	.671	83	2.06	318	66	11	7	692		246	22	115	8	18		3,039	5	3.79	1.37	2.77	0.26	10.5	3.8	1.07	.260	2.93	8.24
15	Christy Mathewson C. Mathewson	749.1	Cubs	96	46	39	.541	87	0.89	355	75	14	5	654		283	18	113	4	8			17	4.26	1.36	3.14	0.22		3.8	1.02	.257	3.40	7.85
16	Eppa Rixey E. Rixey	741.0	Pirates	113	36	53	.404	96	3.04	202	44	7	0	801		338	11	158	15	10			21	2.45	1.92	1.28	0.13		5.0	1.29	.286	4.11	9.73
17	Early Wynn E. Wynn	733.1	Yankees	113	33	58	.363	99	4.22	372	42	6	2	713	344	385	84	305	8	11	8	3,174	9	4.57	3.74	1.22	1.03	11.7	9.6	1.39	.262	4.73	8.75
18	Christy Mathewson C. Mathewson	726.1	Reds	95	65	19	.774	83	0.89	354	69	12	5	633		234	14	121	12	11			12	4.39	1.50	2.93	0.17		4.2	1.04	.263	2.90	7.84
19	Grover Alexander G. Alexander	723.0	Giants	99	39	43	.476	86	3.20	261	56	8	4	769		329	33	171	11	8		3,019	8	3.25	2.13	1.53	0.41	8.6	5.7	1.30	.289	4.10	9.57
20	Grover Alexander G. Alexander	723.0	Robins	95	56	23	.709	81	2.02	308	63	16	6	654		233	13	122	6	13			8	3.83	1.52	2.52	0.16		4.2	1.07	.260	2.90	8.14
21	Warren Spahn W. Spahn	718.0	Pirates	104	49	34	.590	95	3.33	382	49	9	5	681	266	302	50	217	4	8		2,991	9	4.79	2.72	1.76	0.63	12.8	7.3	1.25	.270	3.79	8.54
22	Lefty Grove L. Grove	702.2	Tigers	102	60	19	.759	79	3.05	390	59	7	5	651	238	275	37	212	7	14		2,936	10	5.00	2.72	1.84	0.47	13.3	7.2	1.23	.268	3.52	8.34
23	Red Faber R. Faber	691.1	Athletics	105	47	30	.610	77	3.22	256	49	7	2	702	247	305	25	198	22	15		2,920	9	3.33	2.58	1.29	0.33	8.8	6.8	1.30	.280	3.97	9.14
24	Eddie Plank E. Plank	691.0	Red Sox	94	49	31	.613	82	1.25	339	65	8	2	596		230	10	154	30	11			15	4.42	2.01	2.20	0.13		5.8	1.09	.277	3.00	7.76
25	Christy Mathewson C. Mathewson	687.0	Braves	90	55	24	.696	78	1.19	410	63	14	3	598		209	9	133	7	9			16	5.37	1.74	3.08	0.12		4.9	1.06	.270	2.74	7.83