Mark Reynolds has the most career strikeouts per at-bat with 5,000+ at-bats, with 0.35.

	NAME	SO/AB	AB	SO	G	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Mark Reynolds M. Reynolds	0.35	5,432	1,927	1,688	794	1,283	253	14	298	871	707	56	64	31	6,243	2,458	565	3	45	26	117	.236	.328	.453	.780	821	94.7	.338	103	24.8
2	Adam Dunn A. Dunn	0.35	6,883	2,379	2,001	1,097	1,631	334	10	462	1,168	1,317	86	63	25	8,328	3,371	806	2	40	122	100	.237	.364	.490	.854	1285	297.9	.367	123	240
3	Giancarlo Stanton G. Stanton	0.33	6,169	2,014	1,692	927	1,594	309	11	441	1,137	792	54	42	15	7,054	3,248	761	0	39	90	155	.258	.346	.527	.872	1124	306.3	.369	136	300.3
4	Ryan Howard R. Howard	0.32	5,707	1,843	1,572	848	1,475	277	21	382	1,194	709	59	12	5	6,530	2,940	680	0	55	154	116	.258	.343	.515	.859	976	212.1	.361	121	175.3
5	Eugenio Suárez E. Suárez	0.31	5,663	1,752	1,589	810	1,401	254	15	313	923	618	102	35	20	6,455	2,624	582	9	63	15	127	.247	.329	.463	.792	894	127.8	.339	113	99.9
6	Jim Thome J. Thome	0.3	8,422	2,548	2,543	1,583	2,328	451	26	612	1,699	1,747	69	19	20	10,313	4,667	1,089	1	74	173	165	.276	.402	.554	.956	1925	653.9	.406	145	589.5
7	B.J. Upton	0.3	5,175	1,561	1,469	723	1,260	262	32	164	586	589	24	300	92	5,854	2,078	458	22	44	23	98	.243	.321	.402	.723	667	-13	.318	98	-12
8	Justin Upton J. Upton	0.29	6,721	1,971	1,845	1,058	1,754	350	38	325	1,003	785	78	151	59	7,646	3,155	713	3	59	49	142	.261	.342	.469	.812	1082	194.2	.350	117	155.9
9	Pat Burrell P. Burrell	0.28	5,503	1,564	1,640	767	1,393	299	16	292	976	932	31	7	3	6,520	2,600	607	0	54	53	119	.253	.361	.472	.834	970	174.8	.360	117	143.8
10	Jay Buhner J. Buhner	0.28	5,013	1,406	1,472	797	1,273	233	19	310	965	792	56	6	24	5,927	2,474	562	12	54	41	123	.254	.359	.494	.852	925	208.8	.371	124	177.9
11	J.D. Martinez	0.28	6,152	1,714	1,642	897	1,741	390	24	331	1,071	601	40	26	11	6,854	3,172	745	0	61	54	195	.283	.348	.516	.863	1084	280	.365	130	246.9
12	Mike Cameron M. Cameron	0.28	6,839	1,901	1,955	1,064	1,700	383	59	278	968	867	87	297	83	7,884	3,035	720	31	60	19	114	.249	.338	.444	.782	1043	70.3	.341	107	69.2
13	Jose Canseco J. Canseco	0.28	7,057	1,942	1,887	1,186	1,877	340	14	462	1,407	906	84	200	88	8,129	3,631	816	1	81	63	178	.266	.353	.515	.867	1293	321.2	.375	130	300.8
14	Mike Trout M. Trout	0.28	5,838	1,606	1,611	1,175	1,726	320	55	398	1,006	1,044	105	214	38	7,047	3,350	773	0	60	130	73	.296	.408	.574	.982	1372	553.7	.412	167	555.2
15	Dave Kingman D. Kingman	0.27	6,677	1,816	1,941	901	1,575	240	25	442	1,210	608	53	85	49	7,429	3,191	707	16	75	72	139	.236	.302	.478	.780	960	139.8	.343	113	108.5
16	Danny Tartabull D. Tartabull	0.27	5,011	1,362	1,406	756	1,366	289	22	262	925	768	17	37	30	5,842	2,485	573	2	44	47	110	.273	.368	.496	.864	940	256.2	.379	133	228.4
17	Ray Lankford R. Lankford	0.27	5,747	1,550	1,701	968	1,561	356	54	238	874	828	36	258	117	6,674	2,739	648	10	53	68	77	.272	.364	.477	.840	1012	196.8	.365	123	190.9
18	Curtis Granderson C. Granderson	0.26	7,236	1,916	2,057	1,217	1,800	346	95	344	937	924	67	153	50	8,306	3,368	785	30	49	31	64	.249	.337	.465	.803	1149	173.1	.347	115	147.8
19	Jayson Werth J. Werth	0.26	5,484	1,450	1,583	883	1,465	300	22	229	799	764	64	132	23	6,366	2,496	551	4	50	32	99	.267	.360	.455	.816	920	180.6	.356	120	148.7
20	Jay Bruce J. Bruce	0.26	5,964	1,572	1,650	839	1,455	312	32	319	951	600	28	65	40	6,641	2,788	663	3	46	71	101	.244	.314	.467	.781	847	79.1	.332	106	47.7
21	Reggie Jackson R. Jackson	0.26	9,864	2,597	2,820	1,551	2,584	463	49	563	1,702	1,375	96	228	115	11,416	4,834	1,075	13	68	164	183	.262	.356	.490	.846	1749	503	.374	139	497.6
22	Dexter Fowler D. Fowler	0.26	5,040	1,326	1,460	817	1,306	253	82	127	517	740	51	149	68	5,902	2,104	462	43	28	16	58	.259	.358	.417	.775	795	111.1	.341	107	51.2
23	Eric Davis E. Davis	0.26	5,321	1,398	1,626	938	1,430	239	26	282	934	740	33	349	66	6,147	2,567	547	3	50	59	112	.269	.359	.482	.841	940	214.4	.368	127	193.9
24	Sammy Sosa S. Sosa	0.26	8,813	2,306	2,354	1,475	2,408	379	45	609	1,667	929	59	234	107	9,896	4,704	1,033	17	78	154	202	.273	.344	.534	.878	1559	345.1	.370	124	307.3
25	Paul Goldschmidt P. Goldschmidt	0.26	7,517	1,962	2,040	1,269	2,166	472	24	372	1,227	1,081	51	174	36	8,705	3,802	868	0	56	121	173	.288	.379	.506	.885	1452	432.7	.376	137	388.2