The Louisville Colonels and the Buffalo Bisons are tied for the lowest run differential in a game with 10+ runs, with a differential of -18 runs.

smallest run differential when scoring 10+ runs MLB by a team in a regular-season game

	TEAM	DIFF	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Colonels	-18	12	6/18/1893	LOU	@	CIN	L 12-30
2	Bisons	-18	12	6/26/1890	BUF	vs	PHP	L 12-30
3	Spiders	-17	11	4/30/1887	CLE	@	STL	L 11-28
4	Senators	-16	11	5/3/1895	WSH	@	BSN	L 11-27
5	Beaneaters	-16	11	6/6/1894	BSN	vs	PIT	L 11-27
6	Grays	-16	11	8/12/1886	BKN	@	LOU	L 11-27
7	Orioles	-14	10	6/26/1978	BAL	@	TOR	L 10-24	38	12	3	0	3	9	5	0	3	0	0	43	24	6	0	0	0	1	.316	.395	.632	1.027
8	Beaneaters	-14	12	6/22/1894	BSN	@	WSH	L 12-26
9	Metropolitans	-14	11	8/31/1887	NYM	@	LOU	L 11-25
10	Alleghenys	-14	14	8/27/1887	PIT	@	BSN	L 14-28
11	Beaneaters	-14	10	7/1/1885	BSN	@	CWS	L 10-24
12	Tigers	-13	11	4/24/1996	DET	vs	MIN	L 11-24	38	14	5	0	3	11	3	1	9	1	0	44	28	8	1	1	0	1	.368	.419	.737	1.155
13	Cubs	-13	10	8/16/1987	CHC	vs	NYM	L 10-23	40	12	3	0	2	9	5	0	11	0	0	45	21	5	0	0	0	0	.300	.378	.525	.903
14	Cubs	-13	10	9/2/1957	CHC	vs	MIL	L 10-23	42	14	2	0	3	10	3	0	7	0	0	45	25	5	0	0	0	0	.333	.378	.595	.973
15	Alleghenys	-13	10	6/14/1883	PIT	vs	COL	L 10-23
16	Rangers	-12	10	7/26/2017	TEX	vs	MIA	L 10-22	35	10	5	0	1	10	8	2	6	0	0	47	18	6	0	2	0	0	.286	.426	.514	.940
17	Mariners	-12	10	8/15/2015	SEA	@	BOS	L 10-22	39	13	1	0	3	9	4	0	10	0	0	43	23	4	0	0	0	2	.333	.395	.590	.985
18	Rockies	-12	12	5/19/1999	COL	vs	CIN	L 12-24	40	15	2	0	3	12	6	0	6	1	0	46	26	5	0	0	0	1	.375	.457	.650	1.107
19	Reds	-12	10	6/5/1912	CIN	@	NYG	L 10-22	41	14	2	1	0	10	2	0	1	0		44	18	3	1				.341	.372	.439	.811
20	Reds	-12	13	6/9/1901	CIN	vs	NYG	L 13-25	44	18	4	0	0	9	5	0	-9	1	-11	49	22	4	0		-11	-11	.409	.469	.500	.969
21	Bisons	-12	16	7/12/1890	BUF	@	BKP	L 16-28
22	Athletics	-12	14	9/30/1888	PHA	@	KCC	L 14-26
23	Royals	-11	11	4/12/1994	KCR	vs	BOS	L 11-22	42	15	3	0	2	11	3	0	4	0	0	45	24	5	0	0	0	0	.357	.400	.571	.971
24	Phillies	-11	10	5/9/1937	PHN	vs	CIN	L 10-21	43	15	1	0	0	9	3	0	2	0	0	46	16	1	0			1	.349	.391	.372	.763
25	Reds	-11	10	9/14/1920	CIN	@	PHN	L 10-21	42	16	4	1	0	8	3	1	2	0	0	48	22	5	2				.381	.435	.524	.959