The Minnesota Twins lost their fewest games against the NL in a season in 2006, with 2 losses.

Interpreted as:

twins all-time record losses in a regular season against nl

	TEAM	L	SEASON	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Twins	2	2006	16	.111	18	.889	630	123	190	34	7	19	118	70	10	106	12	6	719	295	60	5	4	6	10	.302	.378	.468	.846
2	Twins	4	2008	14	.222	18	.778	608	98	171	31	8	15	94	56	4	100	7	4	690	263	54	10	12	3	12	.281	.340	.433	.772
3	Twins	6	2009	12	.333	18	.667	591	88	161	28	7	21	81	64	3	100	6	2	676	266	56	10	8	5	23	.272	.342	.450	.792
4	Twins	7	2020	13	.350	20	.650	667	100	167	35	2	25	95	70	10	186	6	4	755	281	62	0	8	3	10	.250	.327	.421	.748
5	Twins	7	2017	13	.350	20	.650	680	110	183	34	5	30	104	76	7	135	12	4	772	317	69	6	3	3	20	.269	.347	.466	.813
6	Twins	7	2007	11	.389	18	.611	621	99	167	30	7	15	91	60	2	87	16	5	693	256	52	6	4	6	10	.269	.333	.412	.746
7	Twins	7	2004	11	.389	18	.611	633	80	163	36	4	19	75	49	9	130	12	4	702	264	59	5	6	1	12	.258	.317	.417	.734
8	Twins	7	1999	10	.412	17	.588	605	101	188	27	4	16	86	53	5	101	16	7	670	271	47	3	4	3	12	.311	.369	.448	.817
9	Twins	8	2003	10	.444	18	.556	642	88	186	36	5	15	84	57	3	131	13	6	712	277	56	6	4	3	11	.290	.348	.431	.780
10	Twins	8	2002	10	.444	18	.556	627	75	156	37	5	15	72	51	5	132	11	7	689	248	57	2	4	3	14	.249	.309	.396	.704
11	Twins	8	1997	7	.533	15	.467	521	76	143	28	5	15	74	34	5	109	15	6	568	226	48	3	5	0	8	.274	.322	.434	.756
12	Twins	9	2012	9	.500	18	.500	664	85	184	34	3	18	84	50	4	129	13	5	731	278	55	7	6	4	13	.277	.329	.419	.747
13	Twins	9	2001	9	.500	18	.500	605	89	173	35	4	25	84	42	8	109	12	6	668	291	64	6	7	5	15	.286	.337	.481	.818
14	Twins	9	1998	7	.563	16	.438	552	51	142	28	0	8	44	40	3	114	15	4	602	194	36	3	4	4	14	.257	.309	.351	.660
15	Twins	10	2021	10	.500	20	.500	686	84	169	38	1	22	80	61	7	189	9	3	765	275	61	2	9	3	13	.246	.311	.401	.711
16	Twins	10	2011	8	.556	18	.444	599	73	146	29	3	17	68	46	2	123	11	8	651	232	49	4	0	2	9	.244	.300	.387	.687
17	Twins	10	2010	8	.556	18	.444	622	83	175	36	1	12	82	65	5	116	5	3	704	249	49	8	4	8	20	.281	.352	.400	.752
18	Twins	10	2005	8	.556	18	.444	630	83	171	36	3	23	79	52	4	119	12	2	702	282	62	7	9	4	19	.271	.327	.448	.774
19	Twins	11	2014	9	.550	20	.450	678	82	168	38	2	13	76	69	10	156	12	3	770	249	53	4	9	3	11	.248	.322	.367	.690
20	Twins	11	2000	7	.611	18	.389	596	62	152	28	5	13	58	63	8	118	11	5	675	229	46	4	4	3	19	.255	.332	.384	.717
21	Twins	12	2022	8	.600	20	.400	662	83	150	38	3	21	79	65	7	170	3	0	739	257	62	2	3	3	12	.227	.301	.388	.689
22	Twins	12	2019	8	.600	20	.400	700	103	179	33	4	39	99	65	8	165	4	4	780	337	76	5	2	4	7	.256	.325	.481	.807
23	Twins	12	2018	8	.600	20	.400	684	100	180	48	1	19	95	66	4	169	6	4	763	287	68	3	6	3	14	.263	.329	.420	.749
24	Twins	12	2016	8	.600	20	.400	725	98	191	37	4	23	93	75	1	188	11	4	812	305	64	5	6	5	9	.263	.331	.421	.752
25	Twins	12	2015	8	.600	20	.400	674	77	166	36	7	16	70	55	5	139	14	6	742	264	59	4	4	4	19	.246	.306	.392	.698