Harmon Killebrew has hit the most career homers for the Twins versus the Cleveland Indians, with 54 home runs.

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Harmon Killebrew H. Killebrew	54	236	793	109	192	18	4	141	115	5	171	2	0	917	380	76	0	4	11	21	.242	.340	.479	.819
2	Bob Allison B. Allison	30	173	569	93	142	22	4	93	103	4	117	12	5	683	262	56	2	5	4	6	.250	.366	.460	.826
3	Torii Hunter T. Hunter	25	145	539	81	159	37	1	94	43	8	92	15	6	593	273	63	0	3	0	16	.295	.354	.506	.861
4	Justin Morneau J. Morneau	24	147	536	72	139	33	0	105	48	5	78	0	0	601	244	57	0	12	8	22	.259	.319	.455	.775
5	Max Kepler M. Kepler	22	123	456	57	95	23	1	49	37	2	105	2	0	497	186	46	0	2	2	6	.208	.270	.408	.678
6	Eddie Rosario E. Rosario	22	93	352	55	106	17	4	47	19	0	80	4	0	371	197	43	0	0	4	3	.301	.337	.560	.897
7	Brian Dozier B. Dozier	22	112	435	61	108	23	2	56	49	6	95	7	5	497	201	47	2	5	3	9	.248	.329	.462	.791
8	Jim Lemon J. Lemon	22	117	401	50	101	8	5	61	39	5	90	0	5	451	185	35	1	5	2	10	.252	.322	.461	.784
9	Miguel Sanó M. Sanó	20	95	335	42	70	19	0	43	54	1	145	2	0	390	149	39	0	0	2	7	.209	.321	.445	.765
10	Tony Oliva T. Oliva	20	164	576	75	168	29	4	90	54	5	75	3	5	643	265	53	2	6	14	12	.292	.354	.460	.814
11	Kent Hrbek K. Hrbek	19	140	489	84	155	30	3	91	58	3	53	3	2	559	248	52	1	8	9	9	.317	.387	.507	.894
12	Mickey Vernon M. Vernon	18	263	1,025	124	286	63	13	134	109	1	103	13	5	1,145	429	94	7	3	2	24	.279	.348	.419	.767
13	Roy Sievers R. Sievers	17	123	453	59	104	21	2	60	53	4	77	0	2	514	180	40	0	4	7	4	.230	.313	.397	.711
14	Jimmie Hall J. Hall	16	68	221	35	57	6	1	34	26	0	43	3	1	249	113	23	1	1	2	5	.258	.335	.511	.846
15	Jorge Polanco J. Polanco	14	95	369	36	96	23	4	51	26	1	75	4	4	401	169	41	1	4	1	7	.260	.308	.458	.765
16	Byron Buxton B. Buxton	14	84	257	33	50	8	0	32	17	4	92	7	1	279	100	22	1	0	0	1	.195	.255	.389	.645
17	Joe Mauer J. Mauer	14	196	749	111	237	53	4	78	101	0	114	4	1	852	340	71	0	2	19	30	.316	.397	.454	.851
18	Kirby Puckett K. Puckett	14	143	601	110	201	38	3	84	26	7	69	8	2	640	287	55	2	4	4	14	.334	.367	.478	.844
19	Eddie Yost E. Yost	14	237	855	126	202	33	8	77	169	12	127	9	5	1,056	293	55	17	3	1	13	.236	.369	.343	.711
20	Gary Gaetti G. Gaetti	13	102	383	44	103	16	2	68	24	4	57	6	5	416	162	31	1	4	4	7	.269	.316	.423	.739
21	Goose Goslin G. Goslin	13	200	746	114	229	38	13	121	73	9	60	10		850	332	64	22				.307	.376	.445	.821
22	Jason Kubel J. Kubel	12	91	294	35	78	18	0	40	28	3	73	1	2	328	132	30	0	3	6	6	.265	.332	.449	.781
23	Michael Cuddyer M. Cuddyer	12	127	463	58	120	28	2	54	29	2	92	9	2	495	188	42	0	1	1	18	.259	.305	.406	.711
24	Tim Laudner T. Laudner	12	60	170	26	47	12	0	42	14	0	34	0	0	189	95	24	3	2	1	2	.276	.328	.559	.887
25	Trevor Plouffe T. Plouffe	11	82	298	34	75	20	0	39	21	6	75	1	0	327	128	31	0	2	0	7	.252	.312	.430	.741