Jamie Moyer has the worst career ERA when winning 250+ games, with an ERA of 4.25.

Interpreted as:

worst career era by a player, minimum 250 wins

	NAME	ERA	W	L	W%	G	GS	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Jamie Moyer J. Moyer	4.25	269	209	.563	696	638	2,441	33	10	0	4074.0	4,231	1,926	2,076	522	1,155	146	15	69	17,356	57	5.39	2.55	2.11	1.15	14.1	6.7	1.32	.283	4.59	97	4.46	102	9.35	-33.5
2	Jack Morris J. Morris	3.90	254	186	.577	549	527	2,478	175	28	0	3824.0	3,567	1,657	1,815	389	1,390	58	10	99	16,120	206	5.83	3.27	1.78	0.92	15.4	8.6	1.30	.269	4.27	96	3.93	95	8.40	93
3	Gus Weyhing G. Weyhing	3.88	264	232	.532	540	505	1,667	449	28	4	4337.0	4,576	1,872	2,796	120	1,570	277	34		19,188	240	3.46	3.26	1.06	0.25	8.7	8.2	1.42	.286	5.80	96	3.82	97	9.50	55.7
4	Andy Pettitte A. Pettitte	3.85	256	153	.626	531	521	2,448	26	4	0	3316.0	3,448	1,418	1,572	288	1,031	55	3	42	14,074	69	6.64	2.80	2.37	0.78	17.4	7.3	1.35	.308	4.27	86	3.73	83	9.36	282.1
5	Red Ruffing R. Ruffing	3.80	273	225	.548	624	538	1,987	335	45	18	4344.0	4,284	1,833	2,115	254	1,541	58	69		18,546	46	4.12	3.19	1.29	0.53	10.7	8.3	1.34	.274	4.38	91	3.93	95	8.88	82.3
6	CC Sabathia	3.74	251	161	.609	561	560	3,093	38	12	0	3577.1	3,404	1,485	1,623	382	1,099	123	0	44	14,989	74	7.78	2.76	2.81	0.96	20.6	7.3	1.26	.294	4.08	87	3.77	87	8.56	223.7
7	Mike Mussina M. Mussina	3.68	270	153	.638	537	536	2,813	57	23	0	3562.2	3,460	1,458	1,559	376	785	60	0	29	14,593	71	7.11	1.98	3.58	0.95	19.3	5.4	1.19	.292	3.94	82	3.57	79	8.74	372.8
8	Ted Lyons T. Lyons	3.67	260	230	.531	594	484	1,073	356	27	25	4161.0	4,489	1,696	2,056	222	1,121	31	91		17,797	55	2.32	2.42	0.96	0.48	6.0	6.3	1.35	.278	4.45	85	4.01	95	9.71	91.7
9	Early Wynn E. Wynn	3.54	300	244	.551	691	611	2,334	289	49	16	4564.0	4,291	1,796	2,037	338	1,775	64	67	36	19,408	51	4.60	3.50	1.31	0.67	12.0	9.1	1.33	.265	4.02	94	3.64	97	8.46	56.4
10	Tom Glavine T. Glavine	3.54	305	203	.600	682	682	2,607	56	25	0	4413.1	4,298	1,734	1,900	356	1,500	66	0	145	18,604	65	5.32	3.06	1.74	0.73	14.0	8.1	1.31	.280	3.87	86	3.94	94	8.76	120.1
11	Burleigh Grimes B. Grimes	3.53	270	212	.560	616	497	1,512	314	35	18	4180.0	4,412	1,638	2,050	148	1,295	101	95		17,974	92	3.26	2.79	1.17	0.32	8.4	7.2	1.37	.286	4.41	94	3.65	96	9.50	70.3
12	Jim Kaat J. Kaat	3.45	283	237	.544	898	625	2,461	180	31	17	4530.1	4,620	1,738	2,038	395	1,083	122	102	116	19,023	128	4.89	2.15	2.27	0.78	12.9	5.7	1.26	.282	4.05	93	3.41	91	9.18	165.8
13	Robin Roberts R. Roberts	3.41	286	245	.539	676	609	2,357	305	45	25	4688.2	4,582	1,774	1,962	505	902	54	49	69	19,174	33	4.52	1.73	2.61	0.97	12.3	4.7	1.17	.265	3.77	89	3.50	91	8.80	179.6
14	Phil Niekro P. Niekro	3.35	318	274	.537	864	716	3,342	245	45	29	5404.0	5,044	2,012	2,337	482	1,809	123	83	86	22,677	226	5.57	3.01	1.85	0.80	14.7	8.0	1.27	.270	3.89	87	3.61	95	8.40	116.1
15	Tommy John T. John	3.34	288	231	.555	760	700	2,245	162	46	3	4710.1	4,783	1,749	2,017	302	1,259	98	22	102	19,692	187	4.29	2.41	1.78	0.58	11.4	6.4	1.28	.284	3.85	90	3.37	89	9.14	208.3
16	Fergie Jenkins F. Jenkins	3.34	284	226	.557	664	594	3,192	267	49	7	4500.2	4,142	1,669	1,853	484	997	84	37	116	18,400	62	6.38	1.99	3.20	0.97	17.3	5.4	1.14	.268	3.71	87	3.27	88	8.28	222.9
17	Justin Verlander J. Verlander	3.32	266	158	.627	555	555	3,553	26	9	0	3567.2	3,046	1,317	1,428	371	1,004	121	0	28	14,607	99	8.96	2.53	3.54	0.94	24.3	6.9	1.14	.280	3.60	79	3.43	81	7.68	310.9
18	Bert Blyleven B. Blyleven	3.31	287	250	.534	692	685	3,701	242	60	0	4970.0	4,632	1,830	2,029	430	1,322	155	3	71	20,491	114	6.70	2.39	2.80	0.78	18.1	6.5	1.20	.282	3.67	85	3.18	82	8.39	368.6
19	Randy Johnson R. Johnson	3.29	303	166	.646	618	603	4,875	100	37	2	4135.1	3,346	1,513	1,703	411	1,497	190	7	37	17,067	109	10.61	3.26	3.26	0.89	28.6	8.8	1.17	.291	3.71	75	3.18	73	7.28	554.3
20	Don Sutton D. Sutton	3.26	324	256	.559	774	756	3,574	178	58	5	5282.1	4,692	1,914	2,104	472	1,343	82	12	102	21,631	112	6.09	2.29	2.66	0.80	16.5	6.2	1.14	.261	3.58	92	3.23	90	7.99	181.2
21	Bob Feller B. Feller	3.25	266	162	.621	570	484	2,581	279	44	22	3827.0	3,271	1,384	1,557	224	1,764	60	52	6	16,180	69	6.07	4.15	1.46	0.53	16.0	10.9	1.32	.264	3.66	82	3.48	89	7.69	184.6
22	Steve Carlton S. Carlton	3.22	329	244	.574	741	709	4,136	254	55	2	5217.2	4,672	1,864	2,130	414	1,833	53	13	150	21,683	183	7.13	3.16	2.26	0.71	19.1	8.5	1.25	.279	3.67	87	3.14	86	8.06	271.5
23	Nolan Ryan N. Ryan	3.19	324	292	.526	807	773	5,714	222	61	3	5386.0	3,923	1,911	2,178	321	2,795	158	13	78	22,575	277	9.55	4.67	2.04	0.54	25.3	12.4	1.25	.265	3.64	90	2.96	83	6.56	370.2
24	Greg Maddux G. Maddux	3.16	355	227	.610	744	740	3,371	109	35	0	5008.1	4,726	1,756	1,981	353	999	137	3	177	20,421	70	6.06	1.80	3.37	0.63	16.5	4.9	1.14	.281	3.56	76	3.25	78	8.49	519.5
25	Red Faber R. Faber	3.15	254	213	.544	669	483	1,471	273	29	27	4086.2	4,106	1,430	1,813	111	1,213	103	134		17,104	52	3.24	2.67	1.21	0.24	8.6	7.1	1.30	.281	3.99	84	3.43	93	9.04	124.6