NVIDIA (NVDA) had the highest return between 2019 and 2024 by a mega-cap US stock, returning 4,044.9%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2019-2024	4,044.88%
Tesla (TSLA)	2019-2024	1,878.97%
Broadcom (AVGO)	2019-2024	1,014.32%
Palantir Technologies Inc Class A Common Stock (PLTR)	2019-2024	656.3%
Blackstone (BX)	2019-2024	634.52%
Eli Lilly and (LLY)	2019-2024	633.59%
Apple (AAPL)	2019-2024	577.08%
Advanced Micro Devices (AMD)	2019-2024	570.68%
Taiwan Semiconductor Manufacturing (TSM)	2019-2024	529.65%
Costco Wholesale (COST)	2019-2024	402.14%
GE Aerospace (GE)	2019-2024	378.86%
ASML Holding NV ADR (ASML)	2019-2024	377.25%
Applovin (APP)	2019-2024	362.61%
Facebook (META)	2019-2024	355.65%
Microsoft (MSFT)	2019-2024	349.73%
Novo Nordisk A-S (NVO)	2019-2024	313.87%
Oracle (ORCL)	2019-2024	311.61%
Goldman Sachs (GS)	2019-2024	301.95%
Morgan Stanley (MS)	2019-2024	289.7%
Alphabet Inc Class A (GOOGL)	2019-2024	269.91%
T-Mobile US (TMUS)	2019-2024	257.82%
Netflix (NFLX)	2019-2024	243.77%
American Express (AXP)	2019-2024	243.49%
Caterpillar (CAT)	2019-2024	235.67%
Walmart (WMT)	2019-2024	225.26%

Mega-cap stocks are treated as having a market cap of $200B+.