Diginex Limited Ordinary Shares (DGNX) has had the highest return this year by a small-cap US stock, returning 2,857.7%.

ASSET	YEAR	% RETURN
Diginex Limited Ordinary Shares (DGNX)	2025	2,857.75%
DeFi Development (DFDV)	2025	2,179.68%
Zepp Health (ZEPP)	2025	1,716.54%
Oncology Institute (TOI)	2025	1,076.47%
Better Home & Finance (BETR)	2025	631.95%
Airnet Technology (ANTE)	2025	627.88%
ThredUp (TDUP)	2025	558.33%
Mobilicom Limited Warrants (MOBBW)	2025	496.17%
Newegg Commerce (NEGG)	2025	460.75%
Nanobiotix (NBTX)	2025	428.62%
IsoEnergy (ISOU)	2025	417.65%
So-Young International (SY)	2025	398.02%
Avino Silver & Gold Mines (ASM)	2025	393.41%
Arena (AREN)	2025	381.88%
QuantaSing Group Limited American Depositary Shares (QSG)	2025	341.63%
China Yuchai International (CYD)	2025	323.86%
Nektar Therapeutics (NKTR)	2025	320.27%
Sify Technologies (SIFY)	2025	319.58%
Immuneering (IMRX)	2025	319.55%
I-Mab (IMAB)	2025	318.82%
NioCorp Developments Ltd Common Stock (NB)	2025	306.29%
Smart Digital Group Limited Ordinary Shares (SDM)	2025	300.75%
ATAI Life Sciences (ATAI)	2025	300.73%
Xunlei Ltd Adr (XNET)	2025	293.63%
Amprius Technologies (AMPX)	2025	285.07%

Small-cap stocks are treated as having a market cap between $300M and $2B.