QXO (QXO) had the highest return between 2012 and 2016 by a large-cap US stock, returning 6,900,200%.

ASSET	YEARS	% RETURN
QXO (QXO)	2012-2016	6,900,200%
Genmab A-S (GMAB)	2012-2016	2,435.57%
Netflix (NFLX)	2012-2016	1,133.07%
IES (IESC)	2012-2016	952.2%
American Airlines (AAL)	2012-2016	820.36%
NVIDIA (NVDA)	2012-2016	701.92%
Texas Pacific Land (TPL)	2012-2016	650.9%
Constellation Brands Inc Class A (STZ)	2012-2016	644.05%
Tesla (TSLA)	2012-2016	638.4%
Incyte (INCY)	2012-2016	566.25%
Broadcom (AVGO)	2012-2016	550.79%
Ionis Pharmaceuticals (IONS)	2012-2016	550.75%
Regeneron Pharmaceuticals (REGN)	2012-2016	549.6%
DexCom (DXCM)	2012-2016	527.1%
Delta Air Lines (DAL)	2012-2016	521.69%
NXP Semiconductors (NXPI)	2012-2016	521.1%
Huntington Ingalls Industries (HII)	2012-2016	506.25%
Southwest Airlines (LUV)	2012-2016	492.36%
Monolithic Power Systems (MPWR)	2012-2016	475.62%
Diamondback Energy (FANG)	2012-2016	467.12%
Domino's Pizza Inc Common Stock (DPZ)	2012-2016	422.2%
Argan (AGX)	2012-2016	420.35%
NetEase (NTES)	2012-2016	417.28%
Saia (SAIA)	2012-2016	412.18%
Charter Communications (CHTR)	2012-2016	400.56%

Large-cap stocks are treated as having a market cap of $10B+.