Monster Beverage (MNST) had the highest return between 2001 and 2007 by a large-cap US stock, returning 9,196.7%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2001-2007	9,196.73%
ArcelorMittal SA ADR (MT)	2001-2007	3,735.97%
Banco Bradesco SA ADR (BBD)	2001-2007	3,505.37%
Deckers Outdoor (DECK)	2001-2007	3,000.94%
Clean Harbors (CLH)	2001-2007	2,802.54%
Cheniere Energy (LNG)	2001-2007	2,642.75%
Apple (AAPL)	2001-2007	2,563.54%
Hologic (HOLX)	2001-2007	2,514.86%
Vale SA ADR (VALE)	2001-2007	2,472.3%
Southern Copper (SCCO)	2001-2007	2,465.51%
Axon Enterprise (AXON)	2001-2007	2,367%
NetEase (NTES)	2001-2007	2,326.65%
Bancolombia SA ADR (CIB)	2001-2007	2,047.74%
Intuitive Surgical (ISRG)	2001-2007	1,887.75%
CME (CME)	2001-2007	1,724.82%
Tractor Supply (TSCO)	2001-2007	1,591.41%
Credicorp (BAP)	2001-2007	1,482.85%
Tenaris SA ADR (TS)	2001-2007	1,465.73%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2001-2007	1,429.7%
ANSYS (ANSS)	2001-2007	1,375.44%
Cameco (CCJ)	2001-2007	1,351.66%
Freeport-McMoran Copper & Gold (FCX)	2001-2007	1,343.94%
Booking (BKNG)	2001-2007	1,292.31%
Elbit Systems (ESLT)	2001-2007	1,249.04%
Telkom Indonesia (Persero) Tbk PT ADR Rep 100 B (TLK)	2001-2007	1,248.39%

Large-cap stocks are treated as having a market cap of $10B+.