Cisco Systems (CSCO) had the highest return between 1992 and 2004 by a mega-cap US stock, returning 4,147.6%.

ASSET	YEARS	% RETURN
Cisco Systems (CSCO)	1992-2004	4,147.58%
Oracle (ORCL)	1992-2004	3,732.46%
UnitedHealth (UNH)	1992-2004	1,809.8%
Amazon (AMZN)	1992-2004	1,716.65%
Microsoft (MSFT)	1992-2004	1,206%
American Express (AXP)	1992-2004	1,062.36%
Raytheon Technologies (RTX)	1992-2004	903.05%
Berkshire Hathaway (BRK.A)	1992-2004	882.12%
Wells Fargo (WFC)	1992-2004	860.31%
Caterpillar (CAT)	1992-2004	790.37%
Micron Technology (MU)	1992-2004	788.14%
Morgan Stanley (MS)	1992-2004	784.8%
JPMorgan Chase (JPM)	1992-2004	757.18%
ASML Holding NV ADR (ASML)	1992-2004	749.05%
GE Aerospace (GE)	1992-2004	668.38%
Bank of America (BAC)	1992-2004	649.14%
Novo Nordisk A-S (NVO)	1992-2004	572.52%
Procter & Gamble (PG)	1992-2004	510.68%
Home Depot (HD)	1992-2004	510.06%
Royal Bank of Canada (RY)	1992-2004	509.86%
LIN TV (LIN)	1992-2004	495.6%
Johnson & Johnson (JNJ)	1992-2004	460.31%
International Business Machines (IBM)	1992-2004	430.85%
AstraZeneca PLC ADR (AZN)	1992-2004	384.57%
Chevron (CVX)	1992-2004	383.1%

Mega-cap stocks are treated as having a market cap of $200B+.