Canadian Pacific Railway (CP) had the highest return in 2016 by a large-cap US stock, returning 469.9%.

ASSET	YEAR	% RETURN
Canadian Pacific Railway (CP)	2016	469.88%
Teck Resources Ltd Class B (TECK)	2016	450.05%
Centrais Electricas Brasileiras (EBR)	2016	423.65%
United States Steel (X)	2016	326.19%
Advanced Micro Devices (AMD)	2016	309.39%
NVIDIA (NVDA)	2016	233.76%
Centrais Elétricas Brasileiras SA - Eletrobrás (EBR.B)	2016	222.94%
Exelixis (EXEL)	2016	171.09%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2016	159.87%
ONEOK (OKE)	2016	149.63%
Banco Santander Brasil SA ADR (BSBR)	2016	148.5%
Vale SA ADR (VALE)	2016	141.81%
Targa Resources (TRGP)	2016	137.12%
Texas Pacific Land Trust (TPL)	2016	136.02%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2016	134.02%
MasTec (MTZ)	2016	123.03%
Banco Bradesco SA ADR (BBD)	2016	116.7%
Steel Dynamics (STLD)	2016	106.35%
Alamos Gold (AGI)	2016	104.19%
Burlington Stores (BURL)	2016	102.56%
Freeport-McMoran Copper & Gold (FCX)	2016	99.85%
Permian Resources (PR)	2016	97.2%
Companhia de Saneamento Basico do Estado de Sao Paulo SABESP ADR (SBS)	2016	94.3%
Kinsale Capital (KNSL)	2016	89.74%
Itau Unibanco Banco (ITUB)	2016	89.06%

Large-cap stocks are treated as having a market cap of $10B+.