best performing large cap medical stocks for past 20 years

QXO (QXO) has had the highest return between September 30, 2005 and September 30, 2025 by a large-cap US stock, returning 1,703,536.4%.

ASSET DATE % RETURN
QXO (QXO)
9/30/2005 - 9/30/2025
1,703,536.36%
Ferguson (FERG)
9/30/2005 - 9/30/2025
1,595,644.68%
Natwest (NWG)
9/30/2005 - 9/30/2025
1,394,900%
NVIDIA (NVDA)
9/30/2005 - 9/30/2025
69,896.15%
Tesla (TSLA)
9/30/2005 - 9/30/2025
34,889.34%
Netflix (NFLX)
9/30/2005 - 9/30/2025
34,255.97%
Booking (BKNG)
9/30/2005 - 9/30/2025
28,795.52%
Broadcom (AVGO)
9/30/2005 - 9/30/2025
27,664.61%
Apple (AAPL)
9/30/2005 - 9/30/2025
16,096.45%
Mastercard (MA)
9/30/2005 - 9/30/2025
15,393.74%
Transdigm (TDG)
9/30/2005 - 9/30/2025
14,794.07%
XPO Logistics (XPO)
9/30/2005 - 9/30/2025
14,067.32%
Monolithic Power Systems (MPWR)
9/30/2005 - 9/30/2025
12,055.73%
MercadoLibre (MELI)
9/30/2005 - 9/30/2025
11,633.38%
Comfort Systems USA (FIX)
9/30/2005 - 9/30/2025
11,441.01%
Axon Enterprise (AXON)
9/30/2005 - 9/30/2025
11,356.32%
Texas Pacific Land Trust (TPL)
9/30/2005 - 9/30/2025
10,732.59%
Coca-Cola Consolidated (COKE)
9/30/2005 - 9/30/2025
10,454.3%
Amazon (AMZN)
9/30/2005 - 9/30/2025
9,862.78%
HEICO (HEI.A)
9/30/2005 - 9/30/2025
9,615.34%
Deckers Outdoor (DECK)
9/30/2005 - 9/30/2025
7,585.1%
Heico (HEI)
9/30/2005 - 9/30/2025
7,256.49%
Monster Beverage (MNST)
9/30/2005 - 9/30/2025
6,872.09%
Tyler Technologies (TYL)
9/30/2005 - 9/30/2025
6,260.94%
ASML Holding NV ADR (ASML)
9/30/2005 - 9/30/2025
6,130.53%
Large-cap stocks are treated as having a market cap of $10B+.