Ovintiv (OVV) had the highest return between 1999 and 2008 by a large-cap US stock, returning 82,345,000%.

ASSET	YEARS	% RETURN
Ovintiv (OVV)	1999-2008	82,345,000%
InterContinental Hotels Group PLC ADR (IHG)	1999-2008	5,519,600%
Natwest (NWG)	1999-2008	1,589,066.67%
National Grid PLC ADR (NGG)	1999-2008	1,018,952.94%
Monster Beverage (MNST)	1999-2008	4,898.57%
Clean Harbors (CLH)	1999-2008	3,804%
Deckers Outdoor (DECK)	1999-2008	3,657.15%
Suzano Papel e Celulose SA ADR (SUZ)	1999-2008	2,003.1%
Gilead Sciences (GILD)	1999-2008	1,895.6%
Laboratory Corporation of America (LH)	1999-2008	1,773.9%
Southern Copper (SCCO)	1999-2008	1,704.64%
Royal Gold (RGLD)	1999-2008	1,331.03%
Cognizant Technology Solutions Corp Class A (CTSH)	1999-2008	1,315.35%
Agnico Eagle Mines (AEM)	1999-2008	1,195.51%
Ambev SA ADR (ABEV)	1999-2008	1,181.31%
Quest Diagnostics (DGX)	1999-2008	1,113.7%
Qualcomm (QCOM)	1999-2008	1,060.64%
Elbit Systems (ESLT)	1999-2008	1,053.47%
Chunghwa Telecom (CHT)	1999-2008	996.6%
BHP (BHP)	1999-2008	960.53%
BlackRock (BLK)	1999-2008	941.4%
Logitech International (LOGI)	1999-2008	938.61%
Altria (MO)	1999-2008	914.14%
NVR (NVR)	1999-2008	856.75%
Coherent (COHR)	1999-2008	854.49%

Large-cap stocks are treated as having a market cap of $10B+.