Super Micro Computer (SMCI) had the highest return between 2021 and 2023 by a large-cap US stock, returning 793.9%.

ASSET	YEARS	% RETURN
Super Micro Computer (SMCI)	2021-2023	793.9%
Symbotic (SYM)	2021-2023	394.03%
Antero Resources (AR)	2021-2023	307.18%
Builders FirstSource (BLDR)	2021-2023	304.7%
Comfort Systems USA (FIX)	2021-2023	296.47%
Marathon Petroleum (MPC)	2021-2023	288.51%
NVIDIA (NVDA)	2021-2023	278.76%
GameStop (GME)	2021-2023	269.05%
Diamondback Energy (FANG)	2021-2023	263.93%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2021-2023	263.79%
Celestica (CLS)	2021-2023	259.26%
Eli Lilly and (LLY)	2021-2023	258.34%
YPF Sociedad Anonima (YPF)	2021-2023	255.9%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2021-2023	247.73%
Devon Energy (DVN)	2021-2023	244.82%
Occidental Petroleum (OXY)	2021-2023	243.73%
Targa Resources (TRGP)	2021-2023	242.73%
Nucor (NUE)	2021-2023	236.71%
Steel Dynamics (STLD)	2021-2023	229.9%
Imperial Oil (IMO)	2021-2023	224.03%
Arista Networks (ANET)	2021-2023	223.99%
Cameco (CCJ)	2021-2023	222.9%
ConocoPhillips (COP)	2021-2023	222.39%
Constellation Energy (CEG)	2021-2023	214.17%
Canadian Natural Resources (CNQ)	2021-2023	213.74%

Large-cap stocks are treated as having a market cap of $10B+.