Expedia (EXPE) had the highest return between 2005 and 2010 by a large-cap US stock, returning 6,141.5%.

ASSET	YEARS	% RETURN
Expedia (EXPE)	2005-2010	6,141.5%
Booking (BKNG)	2005-2010	1,584.44%
Baidu (BIDU)	2005-2010	1,362.58%
Banco Bradesco SA ADR (BBD)	2005-2010	1,333.24%
Netflix (NFLX)	2005-2010	1,307.74%
Illumina (ILMN)	2005-2010	1,244.8%
Wheaton Precious Metals (WPM)	2005-2010	1,159.34%
Monster Beverage (MNST)	2005-2010	1,018.54%
Hudbay Minerals (HBM)	2005-2010	962.04%
Paramount Skydance Corporation Class B Common Stock (PSKY)	2005-2010	904.36%
Apple (AAPL)	2005-2010	895.87%
Southern Copper (SCCO)	2005-2010	850.39%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2005-2010	848.25%
Credicorp (BAP)	2005-2010	800.02%
First Majestic Silver (AG)	2005-2010	796.29%
CF Industries (CF)	2005-2010	749.97%
Salesforce (CRM)	2005-2010	704.38%
Trip Group Ltd ADR (TCOM)	2005-2010	616.3%
Suzano Papel e Celulose SA ADR (SUZ)	2005-2010	601.61%
Intuitive Surgical (ISRG)	2005-2010	544.06%
Ambev SA ADR (ABEV)	2005-2010	543.97%
Alamos Gold (AGI)	2005-2010	539%
TechnipFMC (FTI)	2005-2010	492.77%
Agnico Eagle Mines (AEM)	2005-2010	471.36%
Tenaris SA ADR (TS)	2005-2010	469.87%

Large-cap stocks are treated as having a market cap of $10B+.