EXACT Sciences (EXAS) has had the highest return this month by a large-cap US stock, returning 55.5%.

ASSET	MONTH	% RETURN
EXACT Sciences (EXAS)	November 2025	55.47%
Globus Medical (GMED)	November 2025	42.89%
Madrigal Pharmaceuticals (MDGL)	November 2025	29.96%
Jazz Pharmaceuticals (JAZZ)	November 2025	28.93%
Penumbra (PEN)	November 2025	27.87%
Coca-Cola Consolidated (COKE)	November 2025	23.92%
Lumentum (LITE)	November 2025	22.47%
Eli Lilly and (LLY)	November 2025	22.47%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	November 2025	22.16%
Solventum (SOLV)	November 2025	20.92%
Revolution Medicines (RVMD)	November 2025	20.26%
Albemarle (ALB)	November 2025	19.77%
Akamai Technologies (AKAM)	November 2025	18.35%
AngloGold Ashanti (AU)	November 2025	17.7%
Expeditors International of Washington (EXPD)	November 2025	17.65%
Teva Pharma Industries Ltd ADR (TEVA)	November 2025	17.52%
Old Republic International (ORI)	November 2025	16.97%
Hyatt Hotels (H)	November 2025	16.32%
Natera (NTRA)	November 2025	16.06%
Jack Henry & Associates (JKHY)	November 2025	15.25%
Regeneron Pharmaceuticals (REGN)	November 2025	15.12%
Cigna (CI)	November 2025	14.56%
Dupont De Nemours (DD)	November 2025	14.4%
Biogen (BIIB)	November 2025	14.13%
Waters (WAT)	November 2025	14.01%

Large-cap stocks are treated as having a market cap of $10B+.