Thomson Reuters Corporation Common Shares (TRI) had the highest return between 2001 and 2002 by a large-cap US stock, returning 16,078.9%.

ASSET	YEARS	% RETURN
Thomson Reuters Corporation Common Shares (TRI)	2001-2002	16,078.88%
Hecla Mining (HL)	2001-2002	799.56%
Tractor Supply (TSCO)	2001-2002	784.97%
Clean Harbors (CLH)	2001-2002	773.57%
Royal Gold (RGLD)	2001-2002	765.89%
Hudbay Minerals (HBM)	2001-2002	350.03%
Gold Fields Ltd ADR (GFI)	2001-2002	339.53%
Kinross Gold (KGC)	2001-2002	335.57%
NetEase (NTES)	2001-2002	266.33%
Boston Scientific (BSX)	2001-2002	214.96%
CACI International (CACI)	2001-2002	200.13%
Wintrust Financial (WTFC)	2001-2002	197.96%
Pan American Silver (PAAS)	2001-2002	188.36%
Old Dominion Freight Line (ODFL)	2001-2002	184.01%
Williams-Sonoma (WSM)	2001-2002	171.5%
NVR (NVR)	2001-2002	164.16%
AngloGold Ashanti (AU)	2001-2002	157.42%
Ross Stores (ROST)	2001-2002	152.47%
AutoZone (AZO)	2001-2002	150.09%
Western Digital (WDC)	2001-2002	149.37%
Agnico Eagle Mines (AEM)	2001-2002	148.82%
HF Sinclair (DINO)	2001-2002	144.51%
Knight Transportation (KNX)	2001-2002	140%
Genesis Healthcare (GEN)	2001-2002	137.42%
Centene (CNC)	2001-2002	135.39%

Large-cap stocks are treated as having a market cap of $10B+.