NetEase (NTES) had the highest return between 2002 and 2011 by a large-cap US stock, returning 23,818.4%.

ASSET	YEARS	% RETURN
NetEase (NTES)	2002-2011	23,818.37%
Monster Beverage (MNST)	2002-2011	17,271.72%
Grupo Cibest (CIB)	2002-2011	5,420.53%
Deckers Outdoor (DECK)	2002-2011	5,028.26%
Clean Harbors (CLH)	2002-2011	3,704.78%
Apple (AAPL)	2002-2011	3,572.94%
Southern Copper (SCCO)	2002-2011	2,737.78%
Ambev SA ADR (ABEV)	2002-2011	2,417.76%
Intuitive Surgical (ISRG)	2002-2011	2,262.16%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2002-2011	2,224%
Alamos Gold (AGI)	2002-2011	2,108.32%
Chunghwa Telecom (CHT)	2002-2011	1,951.25%
Cognizant Technology Solutions Corp Class A (CTSH)	2002-2011	1,786.15%
Vale SA ADR (VALE)	2002-2011	1,734.14%
Cheniere Energy (LNG)	2002-2011	1,729.64%
Baidu (BIDU)	2002-2011	1,664.7%
Credicorp (BAP)	2002-2011	1,568.38%
Tractor Supply (TSCO)	2002-2011	1,564.04%
Amazon (AMZN)	2002-2011	1,482.85%
Old Dominion Freight Line (ODFL)	2002-2011	1,439.35%
Royal Gold (RGLD)	2002-2011	1,321.32%
Tenaris SA ADR (TS)	2002-2011	1,316.5%
ArcelorMittal SA ADR (MT)	2002-2011	1,297.93%
TechnipFMC (FTI)	2002-2011	1,275.44%
Canadian Natural Resources (CNQ)	2002-2011	1,257.67%

Large-cap stocks are treated as having a market cap of $10B+.