InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2002 and 2006 by a large-cap US stock, returning 16,461,200%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2002-2006	16,461,200%
National Grid PLC ADR (NGG)	2002-2006	1,632,978.57%
NetEase (NTES)	2002-2006	9,874.24%
Monster Beverage (MNST)	2002-2006	6,250%
Cheniere Energy (LNG)	2002-2006	5,977.37%
ArcelorMittal SA ADR (MT)	2002-2006	2,485.42%
Grupo Cibest (CIB)	2002-2006	2,354.73%
Tenaris SA ADR (TS)	2002-2006	1,615.55%
Banco Bradesco SA ADR (BBD)	2002-2006	1,511.84%
Clean Harbors (CLH)	2002-2006	1,345.07%
Deckers Outdoor (DECK)	2002-2006	1,256.11%
CME (CME)	2002-2006	1,248.04%
Sterling Construction (STRL)	2002-2006	1,172.51%
Southern Copper (SCCO)	2002-2006	1,166.06%
WESCO International (WCC)	2002-2006	1,076.19%
Cognizant Technology Solutions Corp Class A (CTSH)	2002-2006	1,031.52%
Vale SA ADR (VALE)	2002-2006	999.98%
Alamos Gold (AGI)	2002-2006	968.01%
Cameco (CCJ)	2002-2006	928.9%
Chunghwa Telecom (CHT)	2002-2006	922.26%
Telkom Indonesia (Persero) Tbk PT ADR Rep 100 B (TLK)	2002-2006	918.71%
Hologic (HOLX)	2002-2006	916.77%
Teck Resources Ltd Class B (TECK)	2002-2006	896.36%
ICICI Bank (IBN)	2002-2006	891.76%
Canadian Natural Resources (CNQ)	2002-2006	833.07%

Large-cap stocks are treated as having a market cap of $10B+.