Expedia (EXPE) had the highest return between 2005 and 2008 by a large-cap US stock, returning 10,835,600%.

ASSET	YEARS	% RETURN
Expedia (EXPE)	2005-2008	10,835,600%
Monster Beverage (MNST)	2005-2008	617.2%
First Solar (FSLR)	2005-2008	463.1%
Illumina (ILMN)	2005-2008	453.08%
Clean Harbors (CLH)	2005-2008	317.37%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2005-2008	298.24%
Banco Bradesco SA ADR (BBD)	2005-2008	283.21%
Agnico Eagle Mines (AEM)	2005-2008	279.71%
Credicorp (BAP)	2005-2008	258.04%
Mastercard (MA)	2005-2008	257.63%
Sterling Infrastructure (STRL)	2005-2008	256.35%
Stifel Financial (SF)	2005-2008	230.66%
Alnylam Pharmaceuticals (ALNY)	2005-2008	222.43%
Intuitive Surgical (ISRG)	2005-2008	217.32%
Booking (BKNG)	2005-2008	210.48%
CF Industries (CF)	2005-2008	206.06%
Southern Copper (SCCO)	2005-2008	195.59%
Gilead Sciences (GILD)	2005-2008	187.78%
Suzano Papel e Celulose SA ADR (SUZ)	2005-2008	186.72%
Royal Gold (RGLD)	2005-2008	185.17%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2005-2008	184.23%
Vertex Pharmaceuticals (VRTX)	2005-2008	183.93%
Biomarin Pharmaceutical (BMRN)	2005-2008	178.56%
Eldorado Gold (EGO)	2005-2008	172.26%
Halozyme Therapeutics (HALO)	2005-2008	166.67%

Large-cap stocks are treated as having a market cap of $10B+.