Intracellular Th (ITCI) had the highest return in December 2021 by a large-cap US stock, returning 27.5%.

ASSET	MONTH	% RETURN
Intracellular Th (ITCI)	December 2021	27.5%
Fortress Transp & Infra Inv (FTAI)	December 2021	25.79%
argenx NV ADR (ARGX)	December 2021	24.78%
Companhia de Saneamento Basico do Estado de Sao Paulo SABESP ADR (SBS)	December 2021	22.74%
Godaddy (GDDY)	December 2021	21.75%
Fair Isaac (FICO)	December 2021	21.14%
Marvell Technology (MRVL)	December 2021	20.26%
America Movil SAB de CV ADR (AMX)	December 2021	19.87%
Builders FirstSource (BLDR)	December 2021	19.79%
Edwards Lifesciences (EW)	December 2021	19.5%
Hyatt Hotels (H)	December 2021	19.29%
Broadcom (AVGO)	December 2021	18.84%
DaVita HealthCare Partners (DVA)	December 2021	18.29%
NRG Energy (NRG)	December 2021	18.22%
Cigna (CI)	December 2021	18.07%
Elbit Systems (ESLT)	December 2021	17.72%
Hormel Foods (HRL)	December 2021	17.42%
Jabil Circuit (JBL)	December 2021	17.31%
Flutter Entertainment (FLUT)	December 2021	17.02%
AbbVie (ABBV)	December 2021	16.95%
Zillow Group Inc Class C (Z)	December 2021	16.38%
Grupo Aeroportuario del Pacifico SAB De CV ADR (PAC)	December 2021	16.33%
Quest Diagnostics (DGX)	December 2021	16.11%
Penumbra (PEN)	December 2021	15.6%
Bristol-Myers Squibb (BMY)	December 2021	15.59%

Large-cap stocks are treated as having a market cap of $10B+.