Ferguson (FERG) had the highest return between 2010 and 2011 by a large-cap US stock, returning 14,703.5%.

ASSET	YEARS	% RETURN
Ferguson (FERG)	2010-2011	14,703.47%
Domino's Pizza Inc Common Stock (DPZ)	2010-2011	298%
Chipotle Mexican Grill (CMG)	2010-2011	276.94%
Cheniere Energy (LNG)	2010-2011	247.61%
Ulta Beauty (ULTA)	2010-2011	237.6%
Neurocrine Biosciences (NBIX)	2010-2011	206.86%
Lululemon Athletica (LULU)	2010-2011	202.2%
United Rentals (URI)	2010-2011	197.88%
Baidu (BIDU)	2010-2011	179.99%
Las Vegas Sands (LVS)	2010-2011	173.91%
Tractor Supply (TSCO)	2010-2011	169.94%
Dollar Tree (DLTR)	2010-2011	156.8%
Fortinet (FTNT)	2010-2011	143.96%
Monster Beverage (MNST)	2010-2011	138.34%
XPO Logistics (XPO)	2010-2011	137.45%
Estee Lauder Companies (EL)	2010-2011	135.22%
EXACT Sciences (EXAS)	2010-2011	132%
Regeneron Pharmaceuticals (REGN)	2010-2011	128.67%
Ross Stores (ROST)	2010-2011	127.51%
Deckers Outdoor (DECK)	2010-2011	120.11%
Somnigroup International (SGI)	2010-2011	118.97%
Fastenal (FAST)	2010-2011	117.27%
Erie Indemnity (ERIE)	2010-2011	112.05%
Clean Harbors (CLH)	2010-2011	111.27%
Booking (BKNG)	2010-2011	110.38%

Large-cap stocks are treated as having a market cap of $10B+.