Canadian Pacific Railway (CP) had the highest return between 2005 and 2007 by a large-cap US stock, returning 4,717.3%.

ASSET	YEARS	% RETURN
Canadian Pacific Railway (CP)	2005-2007	4,717.3%
First Solar (FSLR)	2005-2007	990.37%
Banco Bradesco SA ADR (BBD)	2005-2007	957.61%
Monster Beverage (MNST)	2005-2007	847.57%
Suzano Papel e Celulose SA ADR (SUZ)	2005-2007	787.62%
Intuitive Surgical (ISRG)	2005-2007	707.11%
CF Industries (CF)	2005-2007	582.55%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2005-2007	541.42%
Illumina (ILMN)	2005-2007	529.09%
Apple (AAPL)	2005-2007	511.57%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2005-2007	497.21%
Southern Copper (SCCO)	2005-2007	493.33%
Baidu (BIDU)	2005-2007	490.61%
Mosaic (MOS)	2005-2007	479.48%
Wheaton Precious Metals (WPM)	2005-2007	475.26%
Biomarin Pharmaceutical (BMRN)	2005-2007	453.99%
GameStop (GME)	2005-2007	441.27%
Credicorp (BAP)	2005-2007	438.89%
Mastercard (MA)	2005-2007	436.88%
Ambev SA ADR (ABEV)	2005-2007	417.38%
Trip Group Ltd ADR (TCOM)	2005-2007	406.67%
Intercontinental Exchange (ICE)	2005-2007	393.6%
Hologic (HOLX)	2005-2007	387.85%
Tenaris SA ADR (TS)	2005-2007	386.37%
Booking (BKNG)	2005-2007	384.23%

Large-cap stocks are treated as having a market cap of $10B+.