Summit Therapeutics (SMMT) had the highest return in December 2022 by a large-cap US stock, returning 444.9%.

ASSET	MONTH	% RETURN
Summit Therapeutics (SMMT)	December 2022	444.87%
Madrigal Pharmaceuticals (MDGL)	December 2022	311%
Roivant Sciences (ROIV)	December 2022	38.96%
Leonardo DRS, Inc Common Stock (DRS)	December 2022	30.67%
Samsara (IOT)	December 2022	30.16%
MongoDB (MDB)	December 2022	27.88%
Arrowhead Pharmaceuticals (ARWR)	December 2022	25.53%
IAMGold (IAG)	December 2022	23.44%
Mitsubishi UFJ Financial Group Inc ADR (MUFG)	December 2022	22.61%
Tencent Music Entertainment (TME)	December 2022	20.7%
DocuSign (DOCU)	December 2022	18.75%
Sumitomo Mitsui Financial (SMFG)	December 2022	17.94%
Mizuho Financial (MFG)	December 2022	16.39%
BeiGene (ONC)	December 2022	15.47%
Haleon (HLN)	December 2022	14.28%
Ciena (CIEN)	December 2022	13.04%
Joint Stock Company Kaspikz (KSPI)	December 2022	12.82%
Trip Group Ltd ADR (TCOM)	December 2022	11.91%
Huazhu (HTHT)	December 2022	11.43%
Okta (OKTA)	December 2022	10.29%
ZTO Express (Cayman) (ZTO)	December 2022	9.63%
Grupo Cibest (CIB)	December 2022	9.54%
Banco De Chile (BCH)	December 2022	9.52%
YPF Sociedad Anonima (YPF)	December 2022	9.02%
Deutsche Bank (DB)	December 2022	8.68%

Large-cap stocks are treated as having a market cap of $10B+.