Ovintiv (OVV) had the highest return between 2001 and 2002 by a large-cap US stock, returning 21,808.6%.

ASSET	YEARS	% RETURN
Ovintiv (OVV)	2001-2002	21,808.65%
Tractor Supply (TSCO)	2001-2002	784.98%
Clean Harbors (CLH)	2001-2002	773.57%
Royal Gold (RGLD)	2001-2002	765.86%
Gold Fields Ltd ADR (GFI)	2001-2002	339.53%
Kinross Gold (KGC)	2001-2002	335.56%
NetEase (NTES)	2001-2002	266.06%
Boston Scientific (BSX)	2001-2002	214.96%
CACI International (CACI)	2001-2002	200.13%
Wintrust Financial (WTFC)	2001-2002	197.96%
Pan American Silver (PAAS)	2001-2002	188.36%
Old Dominion Freight Line (ODFL)	2001-2002	183.99%
Williams-Sonoma (WSM)	2001-2002	171.5%
NVR (NVR)	2001-2002	164.16%
AngloGold Ashanti (AU)	2001-2002	155.51%
Ross Stores (ROST)	2001-2002	152.48%
AutoZone (AZO)	2001-2002	150.09%
Western Digital (WDC)	2001-2002	149.35%
Agnico Eagle Mines (AEM)	2001-2002	148.82%
HF Sinclair (DINO)	2001-2002	144.47%
Knight-Swift Transportation (KNX)	2001-2002	140%
Genesis Healthcare (GEN)	2001-2002	137.42%
Centene (CNC)	2001-2002	135.39%
Tyler Technologies (TYL)	2001-2002	130.07%
Tapestry (TPR)	2001-2002	130%

Large-cap stocks are treated as having a market cap of $10B+.