Expedia (EXPE) had the highest return between 2005 and 2006 by a large-cap US stock, returning 5,090.5%.

ASSET	YEARS	% RETURN
Expedia (EXPE)	2005-2006	5,090.46%
Hudbay Minerals (HBM)	2005-2006	983.4%
Monster Beverage (MNST)	2005-2006	620.38%
Suzano Papel e Celulose SA ADR (SUZ)	2005-2006	444.85%
Tenaris SA ADR (TS)	2005-2006	432.91%
Banco Bradesco SA ADR (BBD)	2005-2006	389.76%
Allegheny Technologies (ATI)	2005-2006	324.78%
Sterling Infrastructure (STRL)	2005-2006	318.46%
Illumina (ILMN)	2005-2006	317.3%
Akamai Technologies (AKAM)	2005-2006	308.62%
Halozyme Therapeutics (HALO)	2005-2006	283.33%
IES (IESC)	2005-2006	274.47%
HF Sinclair (DINO)	2005-2006	273.69%
Wheaton Precious Metals (WPM)	2005-2006	255.25%
Vertex Pharmaceuticals (VRTX)	2005-2006	249.72%
Clean Harbors (CLH)	2005-2006	218.49%
NVIDIA (NVDA)	2005-2006	204.15%
Agnico Eagle Mines (AEM)	2005-2006	203.34%
CBRE Group Inc Class A (CBRE)	2005-2006	196.87%
Nasdaq (NDAQ)	2005-2006	193.23%
Woori Financial (WF)	2005-2006	187.4%
Southern Copper (SCCO)	2005-2006	183.93%
Credicorp (BAP)	2005-2006	181%
Alnylam Pharmaceuticals (ALNY)	2005-2006	179.01%
Alamos Gold (AGI)	2005-2006	177.67%

Large-cap stocks are treated as having a market cap of $10B+.