Summit Therapeutics (SMMT) has had the highest return between 2024 and 2025 by a large-cap US stock, returning 915.5%.

ASSET	YEARS	% RETURN
Summit Therapeutics (SMMT)	2024-2025	915.5%
Ast Spacemobile (ASTS)	2024-2025	889.42%
Rocket Lab USA (RKLB)	2024-2025	842.94%
Applovin (APP)	2024-2025	824.79%
Palantir Technologies Inc Class A Common Stock (PLTR)	2024-2025	805.72%
Robinhood Markets (HOOD)	2024-2025	761.38%
Circle Internet (CRCL)	2024-2025	621.87%
Carvana (CVNA)	2024-2025	573.36%
MicroStrategy (MSTR)	2024-2025	511.16%
Hims Hers Health (HIMS)	2024-2025	472.5%
Celestica (CLS)	2024-2025	459.08%
Vistra Energy (VST)	2024-2025	410.69%
GE Vernova LLC (GEV)	2024-2025	400.41%
Credo Technology (CRDO)	2024-2025	391.17%
Reddit (RDDT)	2024-2025	336%
Sea (SE)	2024-2025	321.38%
Carpenter Technology (CRS)	2024-2025	314.97%
Flex (FLEX)	2024-2025	289.81%
IONQ (IONQ)	2024-2025	276.6%
Spotify Technology (SPOT)	2024-2025	269.84%
Howmet Aerospace (HWM)	2024-2025	255.39%
NVIDIA (NVDA)	2024-2025	250.24%
Sprouts Farmers Market LLC (SFM)	2024-2025	245.39%
Ubiquiti Networks (UI)	2024-2025	238.41%
Insmed (INSM)	2024-2025	232.97%

Large-cap stocks are treated as having a market cap of $10B+.