Apple (AAPL) had the highest return between 1998 and 2007 by a mega-cap US stock, returning 5,712.8%.

ASSET	YEARS	% RETURN
Apple (AAPL)	1998-2007	5,712.82%
NVIDIA (NVDA)	1998-2007	1,844.39%
Amazon (AMZN)	1998-2007	1,752.8%
UnitedHealth (UNH)	1998-2007	840.32%
Alphabet Inc Class A (GOOGL)	1998-2007	591.38%
Oracle (ORCL)	1998-2007	505.5%
Mastercard (MA)	1998-2007	436.9%
Royal Bank of Canada (RY)	1998-2007	415.23%
Novo Nordisk A-S (NVO)	1998-2007	412.21%
Raytheon Technologies (RTX)	1998-2007	389.15%
Lam Research (LRCX)	1998-2007	339.65%
Salesforce (CRM)	1998-2007	317.94%
Exxon Mobil (XOM)	1998-2007	254.21%
Chevron (CVX)	1998-2007	235.41%
Netflix (NFLX)	1998-2007	228.98%
Costco Wholesale (COST)	1998-2007	224.18%
Caterpillar (CAT)	1998-2007	210.05%
Berkshire Hathaway (BRK.A)	1998-2007	207.83%
Berkshire Hathaway (BRK.B)	1998-2007	207.73%
Goldman Sachs (GS)	1998-2007	202.27%
Taiwan Semiconductor Manufacturing (TSM)	1998-2007	190.85%
Cisco Systems (CSCO)	1998-2007	186.83%
McDonald’s (MCD)	1998-2007	184.13%
ASML Holding NV ADR (ASML)	1998-2007	165.83%
Walmart Inc Common Stock (WMT)	1998-2007	162.93%

Mega-cap stocks are treated as having a market cap of $200B+.