Apple (AAPL) had the highest return between 2009 and 2011 by a mega-cap US stock, returning 371.6%.

ASSET	YEARS	% RETURN
Apple (AAPL)	2009-2011	371.58%
Seagate Technology (STX)	2009-2011	276.23%
Amazon (AMZN)	2009-2011	237.1%
American Express (AXP)	2009-2011	172.01%
Mastercard (MA)	2009-2011	160.88%
Advanced Micro Devices (AMD)	2009-2011	146.58%
ASML Holding NV ADR (ASML)	2009-2011	144.98%
KLA (KLAC)	2009-2011	142.18%
Micron Technology (MU)	2009-2011	137.36%
Netflix (NFLX)	2009-2011	134.74%
International Business Machines (IBM)	2009-2011	131.7%
Caterpillar (CAT)	2009-2011	120.07%
Alphabet Inc Class A (GOOGL)	2009-2011	109.3%
Marvell Technology (MRVL)	2009-2011	107.64%
Philip Morris International (PM)	2009-2011	107.29%
Analog Devices (ADI)	2009-2011	105.74%
Home Depot (HD)	2009-2011	101.06%
Texas Instruments (TXN)	2009-2011	99.24%
Visa Inc Class A (V)	2009-2011	95.97%
Royal Bank of Canada (RY)	2009-2011	95.07%
UnitedHealth (UNH)	2009-2011	94.92%
LIN TV (LIN)	2009-2011	90.73%
Taiwan Semiconductor Manufacturing (TSM)	2009-2011	86.26%
Intel (INTC)	2009-2011	82.2%
Broadcom (AVGO)	2009-2011	77.57%

Mega-cap stocks are treated as having a market cap of $200B+.