Spyre Therapeutics (SYRE) had the highest return in June 2023 by a mid-cap US stock, returning 246.9%.

ASSET	MONTH	% RETURN
Spyre Therapeutics (SYRE)	June 2023	246.92%
Applied Opt (AAOI)	June 2023	172.15%
TMC the metals (TMC)	June 2023	143.28%
Bitdeer Technologies Group Class A Ordinary Shares (BTDR)	June 2023	126.72%
Aurora Innovation (AUR)	June 2023	102.76%
Eos Energy Enterprises (EOSE)	June 2023	94.62%
Vera Therapeutics (VERA)	June 2023	92.22%
Olema Pharmaceuticals (OLMA)	June 2023	74.32%
D-Wave Quantum (QBTS)	June 2023	64.57%
Opendoor Technologies (OPEN)	June 2023	59.52%
Hut 8 Corp Common Stock (HUT)	June 2023	57.14%
SoundHound AI (SOUN)	June 2023	53.72%
Immunome (IMNM)	June 2023	51.82%
Banco Macro SA B ADR (BMA)	June 2023	49.6%
Chart Industries (GTLS)	June 2023	46.91%
Grupo Financiero Galicia SA ADR (GGAL)	June 2023	45.39%
Gitlab (GTLB)	June 2023	41.62%
BBVA Banco Frances SA ADR (BBAR)	June 2023	39.95%
Archer Aviation (ACHR)	June 2023	38.72%
Hesai Group American Depositary Share, each ADS represents one Class B ordinary share (HSAI)	June 2023	38.37%
Generac (GNRC)	June 2023	37.93%
Tecnoglass (TGLS)	June 2023	36.76%
nCino (NCNO)	June 2023	36.66%
Centessa Pharmaceuticals PLC ADR (CNTA)	June 2023	36.64%
SkyWest (SKYW)	June 2023	36.55%

Mid-cap stocks are treated as having a market cap between $2B and $10B.