SS Innovations International Inc Common Stock (SSII) had the highest return in 2022 by a mid-cap US stock, returning 126,150%.

ASSET	YEAR	% RETURN
SS Innovations International Inc Common Stock (SSII)	2022	126,150%
Verona Pharma PLC ADR (VRNA)	2022	284.83%
Madrigal Pharmaceuticals (MDGL)	2022	238.09%
TransMedics (TMDX)	2022	221.29%
Vista Oil Gas ADR (VIST)	2022	195.47%
Rhythm Pharmaceuticals (RYTM)	2022	191.2%
ADMA Biologics (ADMA)	2022	177.14%
Catalyst Pharmaceuticals (CPRX)	2022	173.93%
Transportadora de Gas del Sur SA ADR (TGS)	2022	163.98%
Akero Therapeutics (AKRO)	2022	157.64%
Biohaven Pharmaceutical (BHVN)	2022	131.33%
Immunovant (IMVT)	2022	107.36%
Axsome Therapeutics (AXSM)	2022	103.35%
Patterson-UTI Energy (PTEN)	2022	101.74%
Vaxcyte (PCVX)	2022	101.47%
Viking Therapeutics (VKTX)	2022	101.28%
F&G Annuities & Life (FG)	2022	100.1%
Modine Manufacturing (MOD)	2022	94.13%
Allegheny Technologies (ATI)	2022	86.39%
Valaris (VAL)	2022	86.28%
Weatherford International (WFRD)	2022	81.99%
Golar LNG (GLNG)	2022	81.74%
Black Stone Minerals (BSM)	2022	80.3%
TAL Education (TAL)	2022	78.93%
Agilysys (AGYS)	2022	76.77%

Mid-cap stocks are treated as having a market cap between $2B and $10B.