Connexa Sports Technologies (YYAI) had the highest return between 2016 and 2021 by a US stock in the Nasdaq Composite (IXIC), returning 34,399,900%.

ASSET	YEARS	% RETURN
Connexa Sports Technologies (YYAI)	2016-2021	34,399,900%
BioNexus Gene Lab Corp Common stock (BGLC)	2016-2021	6,234,046.34%
GeoVax Labs (GOVX)	2016-2021	1,108,063.27%
AquaBounty Technologies (AQB)	2016-2021	583,233.33%
Immatics (IMTX)	2016-2021	268,700%
MDxHealth SA ADR (MDXH)	2016-2021	226,566.67%
Guardforce AI (GFAI)	2016-2021	207,592.31%
CIMG (IMG)	2016-2021	160,900%
Bone Biologics (BBLG)	2016-2021	123,529.26%
INVO Fertility (IVF)	2016-2021	84,603.64%
DeFi Technologies (DEFT)	2016-2021	47,800%
ImmunoPrecise Antibodies (HYFT)	2016-2021	35,633.33%
Applied Digital (APLD)	2016-2021	32,130.77%
Blackboxstocks (BLBX)	2016-2021	31,079.04%
Alarum Technologies (ALAR)	2016-2021	20,843.95%
Avalon GloboCare (ALBT)	2016-2021	17,471.43%
HIVE Blockchain Technologies (HIVE)	2016-2021	16,400%
Aura Minerals Inc Common Shares (AUGO)	2016-2021	12,518.62%
Kaival Brands Innovations (KAVL)	2016-2021	10,251.39%
eXp World (EXPI)	2016-2021	7,934.12%
Xpel (XPEL)	2016-2021	6,402.86%
Eastside Distilling (BLNE)	2016-2021	5,846.55%
FingerMotion (FNGR)	2016-2021	5,588%
Enphase Energy (ENPH)	2016-2021	5,233.53%
Advanced Micro Devices (AMD)	2016-2021	5,094.95%