Azitra (AZTR) had the highest return between 2020 and 2023 by a US stock, returning 3,285,614.3%.

ASSET	YEARS	% RETURN
Azitra (AZTR)	2020-2023	3,285,614.29%
MDxHealth SA ADR (MDXH)	2020-2023	358,081.82%
Integra Resources (ITRG)	2020-2023	176,566.67%
BioNexus Gene Lab Corp Common stock (BGLC)	2020-2023	129,168.29%
Applied Digital (APLD)	2020-2023	93,511.11%
Next Technology (NXTT)	2020-2023	71,051.36%
Lottery (SEGG)	2020-2023	51,420.91%
Heart Test Laboratories Inc Common Stock (HSCS)	2020-2023	50,194.12%
Guardforce AI (GFAI)	2020-2023	15,861.54%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	2020-2023	7,452.87%
INVO Fertility (IVF)	2020-2023	5,525%
Castellum (CTM)	2020-2023	5,318.18%
Connexa Sports Technologies (YYAI)	2020-2023	3,960%
Alpha Metallurgical Resources (AMR)	2020-2023	3,862.45%
Celsius (CELH)	2020-2023	3,286.34%
Clean Energy Technologies, Inc Common Stock (CETY)	2020-2023	3,111.99%
JIN MEDICAL INTERNATIONAL LTD Ordinary Shares (ZJYL)	2020-2023	3,000.63%
COSCIENS Biopharma (CSCI)	2020-2023	2,700%
Sigma Lithium Resources (SGML)	2020-2023	2,325.38%
CPI Card (PMTS)	2020-2023	2,032.22%
DeFi Technologies (DEFT)	2020-2023	2,029.83%
Atlas Lithium Corporation Common Stock (ATLX)	2020-2023	1,985.33%
Empire Petroleum (EP)	2020-2023	1,731.67%
Celldex Therapeutics (CLDX)	2020-2023	1,670.54%
374Water Inc Common Stock (SCWO)	2020-2023	1,477.78%