InterContinental Hotels Group PLC ADR (IHG) had the highest return between 1991 and 2022 by a US stock, returning 54,290,500%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	1991-2022	54,290,500%
Roboai (AIIO)	1991-2022	17,883,233.33%
Johnson Controls International (JCI)	1991-2022	10,003,133.33%
Universal Insurance (UVE)	1991-2022	9,577,400%
Hirequest (HQI)	1991-2022	7,460,000%
TCTM Kids IT Education (VSA)	1991-2022	7,296,775%
GeoVax Labs (GOVX)	1991-2022	3,526,019.4%
Eldorado Gold (EGO)	1991-2022	2,781,966.67%
BioNexus Gene Lab Corp Common stock (BGLC)	1991-2022	2,780,387.8%
KULR Technology (KULR)	1991-2022	2,399,900%
Nutex Health (NUTX)	1991-2022	1,899,900%
Akari Therapeutics (AKTX)	1991-2022	1,503,900%
Zivo Bioscience (ZIVO)	1991-2022	1,363,536.36%
QXO (QXO)	1991-2022	1,102,329.41%
Sequans Communications (SQNS)	1991-2022	999,900%
MDxHealth SA ADR (MDXH)	1991-2022	734,344.44%
Future Fintech (FTFT)	1991-2022	591,900%
Ridgetech (RDGT)	1991-2022	487,400.05%
Connexa Sports Technologies (YYAI)	1991-2022	467,900%
Fubotv (FUBO)	1991-2022	347,900%
Advantage Solutions (ADV)	1991-2022	329,013.92%
Live Ventures (LIVE)	1991-2022	287,055.96%
Jack Henry & Associates (JKHY)	1991-2022	270,183.92%
Suncor Energy (SU)	1991-2022	262,383.81%
Heart Test Laboratories Inc Common Stock (HSCS)	1991-2022	246,958.82%