InterContinental Hotels Group PLC ADR (IHG) had the highest return between 1991 and 2022 by a US stock, returning 54,290,500%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	1991-2022	54,290,500%
Johnson Controls International (JCI)	1991-2022	10,003,133.33%
Universal Insurance (UVE)	1991-2022	9,577,400%
QXO (QXO)	1991-2022	9,370,550%
Hirequest (HQI)	1991-2022	7,460,000%
TCTM Kids IT Education (VSA)	1991-2022	7,296,775%
Cenntro Electric (CENN)	1991-2022	5,764,092.14%
GeoVax Labs (GOVX)	1991-2022	3,526,019.4%
Eldorado Gold (EGO)	1991-2022	2,781,966.67%
KULR Technology (KULR)	1991-2022	2,399,900%
Akari Therapeutics (AKTX)	1991-2022	1,503,900%
Zivo Bioscience (ZIVO)	1991-2022	1,363,536.36%
Sequans Communications (SQNS)	1991-2022	999,900%
Astrana Health (ASTH)	1991-2022	896,566.67%
XORTX Therapeutics (XRTX)	1991-2022	874,873.26%
MDxHealth SA ADR (MDXH)	1991-2022	734,344.44%
Xcel Brands (XELB)	1991-2022	700,100%
Future Fintech (FTFT)	1991-2022	591,900%
Ridgetech (RDGT)	1991-2022	488,081.82%
Connexa Sports Technologies (YYAI)	1991-2022	467,900%
Addentax (ATXG)	1991-2022	459,328.57%
Neuroone Medical Technologies (NMTC)	1991-2022	423,429.41%
Next Technology (NXTT)	1991-2022	358,304.56%
Fubotv (FUBO)	1991-2022	347,900%
Advantage Solutions (ADV)	1991-2022	329,013.92%