ENDRA Life Sciences (NDRA) had the highest return in December 2022 by a US stock in the Nasdaq Composite (IXIC), returning 2,052.8%.

ASSET	MONTH	% RETURN
ENDRA Life Sciences (NDRA)	December 2022	2,052.75%
Kala Pharmaceuticals (KALA)	December 2022	618.46%
Summit Therapeutics (SMMT)	December 2022	444.87%
Pharvaris (PHVS)	December 2022	425.7%
Madrigal Pharmaceuticals (MDGL)	December 2022	311%
BeyondSpring (BYSI)	December 2022	229.82%
American Coastal Insurance (ACIC)	December 2022	229.54%
Shineco (SISI)	December 2022	218.08%
ProQR Therapeutics (PRQR)	December 2022	205.79%
Edesa Biotech (EDSA)	December 2022	132.26%
Viking Therapeutics (VKTX)	December 2022	131.53%
Rent the Runway (RENT)	December 2022	124.26%
Rigel Pharmaceuticals (RIGL)	December 2022	119.62%
Profound Medical (PROF)	December 2022	118.24%
Akebia Ther (AKBA)	December 2022	113.78%
Cabaletta Bio (CABA)	December 2022	101.97%
Verona Pharma PLC ADR (VRNA)	December 2022	101.62%
Clean Energy Technologies, Inc Common Stock (CETY)	December 2022	100%
ClearOne (CLRO)	December 2022	100%
Immix Biopharma (IMMX)	December 2022	94.07%
Hoth Therapeutics (HOTH)	December 2022	91.65%
Avidity Biosciences (RNA)	December 2022	90.47%
iQIYI (IQ)	December 2022	82.76%
Evoke Pharma (EVOK)	December 2022	79.73%
17 Education Technology (YQ)	December 2022	79.58%