Booking (BKNG) had the highest return between 2007 and 2016 by a US stock in the S&P 500 (GSPC), returning 3,233.5%.

ASSET	YEARS	% RETURN
Booking (BKNG)	2007-2016	3,233.47%
Netflix (NFLX)	2007-2016	3,233.06%
Amazon (AMZN)	2007-2016	1,838.65%
Regeneron Pharmaceuticals (REGN)	2007-2016	1,741.89%
Transdigm (TDG)	2007-2016	1,660.29%
Incyte (INCY)	2007-2016	1,611.09%
MarketAxess (MKTX)	2007-2016	1,130.94%
Broadcom (AVGO)	2007-2016	1,080.43%
Tesla (TSLA)	2007-2016	1,024.65%
Domino's Pizza Inc Common Stock (DPZ)	2007-2016	1,014.26%
Mastercard (MA)	2007-2016	982.03%
Skyworks Solutions (SWKS)	2007-2016	968.27%
Apple (AAPL)	2007-2016	931.5%
Tyler Technologies (TYL)	2007-2016	912.55%
Ross Stores (ROST)	2007-2016	894.79%
Smith AO (AOS)	2007-2016	783.21%
O’Reilly Automotive (ORLY)	2007-2016	765.18%
Charter Communications (CHTR)	2007-2016	722.63%
Edwards Lifesciences (EW)	2007-2016	701.88%
Monolithic Power Systems (MPWR)	2007-2016	694.04%
Monster Beverage (MNST)	2007-2016	686.87%
Old Dominion Freight Line (ODFL)	2007-2016	682.46%
Ulta Beauty (ULTA)	2007-2016	681.19%
Dollar Tree (DLTR)	2007-2016	662.65%
NXP Semiconductors (NXPI)	2007-2016	653.92%