Hirequest (HQI) had the highest return between 2000 and 2022 by a US stock, returning 7,498,550%.

ASSET	YEARS	% RETURN
Hirequest (HQI)	2000-2022	7,498,550%
BioNexus Gene Lab Corp Common stock (BGLC)	2000-2022	2,780,387.8%
KULR Technology (KULR)	2000-2022	2,399,900%
Nutex Health (NUTX)	2000-2022	1,899,900%
Zivo Bioscience (ZIVO)	2000-2022	1,363,536.36%
GeoVax Labs (GOVX)	2000-2022	1,243,321.05%
QXO (QXO)	2000-2022	1,102,329.41%
Sequans Communications (SQNS)	2000-2022	999,900%
Cemtrex (CETX)	2000-2022	750,134.6%
MDxHealth SA ADR (MDXH)	2000-2022	734,344.44%
Live Ventures (LIVE)	2000-2022	488,962.5%
Connexa Sports Technologies (YYAI)	2000-2022	467,900%
Heart Test Laboratories Inc Common Stock (HSCS)	2000-2022	246,958.82%
AquaBounty Technologies (AQB)	2000-2022	212,122.22%
Immatics (IMTX)	2000-2022	174,100%
Iqstel (IQST)	2000-2022	146,895.96%
Eastside Distilling (BLNE)	2000-2022	137,437.54%
Integra Resources (ITRG)	2000-2022	126,500%
Aurora Cannabis (ACB)	2000-2022	122,966.67%
Monster Beverage (MNST)	2000-2022	113,722.87%
Gladstone Capital (GLAD)	2000-2022	96,608.05%
Perspective Therapeutics (CATX)	2000-2022	83,233.33%
Ring Energy (REI)	2000-2022	81,900%
Blackboxstocks (BLBX)	2000-2022	70,488.24%
India Globalization Capital (IGC)	2000-2022	53,233.33%