Clean Harbors (CLH) had the highest return between 2000 and 2002 by a large-cap US stock, returning 1,176.7%.

ASSET	YEARS	% RETURN
Clean Harbors (CLH)	2000-2002	1,176.67%
Royal Gold (RGLD)	2000-2002	614.62%
NVR (NVR)	2000-2002	583.77%
Eldorado Gold (EGO)	2000-2002	533.92%
Tractor Supply (TSCO)	2000-2002	368.09%
Hudbay Minerals (HBM)	2000-2002	350.03%
Quest Diagnostics (DGX)	2000-2002	269.33%
DaVita HealthCare Partners (DVA)	2000-2002	265.48%
HF Sinclair (DINO)	2000-2002	258.21%
CoreSite Realty (COR)	2000-2002	251.05%
Brown & Brown (BRO)	2000-2002	246.53%
Gold Fields Ltd ADR (GFI)	2000-2002	236.27%
East West Bancorp (EWBC)	2000-2002	235.31%
Bio-Rad Laboratories (BIO)	2000-2002	231.12%
Tapestry (TPR)	2000-2002	229.2%
Lennar (LEN)	2000-2002	221.68%
CACI International (CACI)	2000-2002	215.05%
UnitedHealth (UNH)	2000-2002	214.82%
Wintrust Financial (WTFC)	2000-2002	213.27%
Hecla Mining (HL)	2000-2002	211.37%
Renaissancere (RNR)	2000-2002	210.25%
Manhattan Associates (MANH)	2000-2002	206.52%
Harmony Gold Mining (HMY)	2000-2002	193.98%
EMCOR (EME)	2000-2002	190.46%
Ryanair Holdings PLC ADR (RYAAY)	2000-2002	188.72%

Large-cap stocks are treated as having a market cap of $10B+.