AquaBounty Technologies (AQB) had the highest return between 2016 and 2017 by a US stock, returning 977,677.8%.

ASSET	YEARS	% RETURN
AquaBounty Technologies (AQB)	2016-2017	977,677.78%
Blackboxstocks (BLBX)	2016-2017	132,214.41%
HIVE Digital Technologies (HIVE)	2016-2017	17,007.5%
ImmunoPrecise Antibodies (HYFT)	2016-2017	15,466.67%
Eastside Distilling (BLNE)	2016-2017	13,288.04%
Metalla Royalty & Streaming (MTA)	2016-2017	5,707.54%
DeFi Technologies (DEFT)	2016-2017	4,960%
Cronos (CRON)	2016-2017	4,556.14%
Quoin Pharmaceuticals Ltd DRC (QNRX)	2016-2017	4,437.04%
FingerMotion (FNGR)	2016-2017	3,300%
Gravity (GRVY)	2016-2017	2,834.78%
Aura Minerals Inc Common Shares (AUGO)	2016-2017	2,673.9%
GrabAGun Digital (PEW)	2016-2017	2,650%
SRx Health Solutions (SRXH)	2016-2017	2,000%
Nixxy (NIXX)	2016-2017	1,900%
Aurora Cannabis (ACB)	2016-2017	1,721%
Datasea (DTSS)	2016-2017	1,687.5%
Arena (AREN)	2016-2017	1,361.54%
Riot Blockchain (RIOT)	2016-2017	1,226.92%
Siebert Financial (SIEB)	2016-2017	1,116.65%
Canopy Growth (CGC)	2016-2017	1,009.05%
Envela (ELA)	2016-2017	990.27%
Village Farms International (VFF)	2016-2017	952.47%
SIGA Technologies (SIGA)	2016-2017	932.11%
Lexaria Bioscience (LEXX)	2016-2017	924.24%