AngloGold Ashanti (AU) had the highest return between 1998 and 2007 by a large-cap US stock, returning 17,612,450%.

ASSET	YEARS	% RETURN
AngloGold Ashanti (AU)	1998-2007	17,612,450%
First Majestic Silver (AG)	1998-2007	20,289.78%
Monster Beverage (MNST)	1998-2007	19,325.26%
Cognizant Technology Solutions Corp Class A (CTSH)	1998-2007	8,044.02%
Apple (AAPL)	1998-2007	5,713.03%
Ovintiv (OVV)	1998-2007	3,877.22%
Hudbay Minerals (HBM)	1998-2007	3,170.64%
Clean Harbors (CLH)	1998-2007	2,963.52%
Banco Bradesco SA ADR (BBD)	1998-2007	2,817.52%
Southern Copper (SCCO)	1998-2007	2,517.3%
Vale SA ADR (VALE)	1998-2007	2,348%
NVR (NVR)	1998-2007	2,295.43%
Johnson Controls International (JCI)	1998-2007	2,236.81%
Sterling Construction (STRL)	1998-2007	2,232.69%
Altria (MO)	1998-2007	1,918.75%
Deckers Outdoor (DECK)	1998-2007	1,900.56%
Logitech International (LOGI)	1998-2007	1,870.64%
NVIDIA (NVDA)	1998-2007	1,844.39%
Rogers Communications (RCI)	1998-2007	1,827.81%
Gilead Sciences (GILD)	1998-2007	1,824.71%
HF Sinclair (DINO)	1998-2007	1,759.38%
Amazon (AMZN)	1998-2007	1,752.8%
CME (CME)	1998-2007	1,724.82%
Intuitive Surgical (ISRG)	1998-2007	1,694.53%
Laboratory Corporation of America (LH)	1998-2007	1,626.75%

Large-cap stocks are treated as having a market cap of $10B+.